ArticlePloS one2012
SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Neuromuscular magnetic stimulation counteracts muscle decline in ALS patients: results of a randomized, double-blind, controlled study.Scientific reports · 2019Trial
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- Transcriptome-wide association study identifies novel genes associated with bone mineral density and lean body mass in children.Endocrine · 2023Article
- Deletion of SREBF1, a Functional Bone-Muscle Pleiotropic Gene, Alters Bone Density and Lipid Signaling in Zebrafish.Endocrinology · 2021Article
- Net protein balance correlates with expression of autophagy, mitochondrial biogenesis, and fat metabolism-related genes in skeletal muscle from older adults.Physiological reports · 2020Article
- Dietary Complex and Slow Digestive Carbohydrates Prevent Fat Deposits During Catch-Up Growth in Rats.Nutrients · 2020Article
- Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle.International journal of molecular sciences · 2020Review
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- Muscle-specific Perilipin2 down-regulation affects lipid metabolism and induces myofiber hypertrophy.Journal of cachexia, sarcopenia and muscle · 2019Article
- Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle.Frontiers in zoology · 2019Article
- Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells.Scientific reports · 2018Article
- Integrative analysis of methylomic and transcriptomic data in fetal sheep muscle tissues in response to maternal diet during pregnancy.BMC genomics · 2018Article
- Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.Nature communications · 2017Article
- Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance.Physiological reports · 2016Article
- Sfrp2 is a transcriptional target of SREBP-1 in mouse chondrogenic cells.Molecular and cellular biochemistry · 2015Article
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- Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2014Article
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- Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations.PloS one · 2013Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SREBP-1 are ubiquitously expressed transcription factors, strongly expressed in lipogenic tissues where they regulate several metabolic processes like fatty acid synthesis. In skeletal muscle, SREBP-1 proteins regulate the expression of hundreds of genes, and we previously showed that their overexpression induced muscle atrophy together with a combined lack of expression of myogenic regulatory factors. Here we present evidences that SREBP-1 regulate muscle protein synthesis through the downregulation of the expression of MYOD1, MYOG and MEF2C factors. In myotubes overexpressing SREBP-1, restoring the expression of myogenic factors prevented atrophy and rescued protein synthesis, without affecting SREBP-1 action on atrogenes and proteolysis. Our results point out the roles of MRFs in the maintenance of the protein content and cell size in adult muscle fibre, and contribute to decipher the mechanisms by which SREBP-1 regulate muscle mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.