ArticlePloS one2012
Contribution of amino acid catabolism to the tissue specific persistence of Campylobacter jejuni in a murine colonization model.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- L-serine at the crossroads of microbiota, intestinal health, and disorders.Communications biology · 2026Review
- Nutrient transporters in broiler chickens: intestinal gene expression profiles, functional roles, and influencing factors.Journal of animal science and biotechnology · 2025Review
- L-serine promotes pro-carcinogenic effects of colibactin-producingGut microbes · 2025Article
- Effects of exogenous protease supplementation of diets containing animal proteins or not on Campylobacter jejuni colonization and on the intestinal microbiota of broiler chickens.Gut pathogens · 2025Article
- AProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pathogenicity and virulence ofVirulence · 2024Review
- Multi-Omics ofMicroorganisms · 2024Article
- QcrC is a potential target for antibody therapy and vaccination to controlFrontiers in microbiology · 2024Article
- Proteomics ofMolecular & cellular proteomics : MCP · 2020Article
- Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut.Nature microbiology · 2020Article
- Analyses of energy metabolism and stress defence provide insights intoGut pathogens · 2020Article
- Proteomics Reveals Multiple Phenotypes Associated withMolecular & cellular proteomics : MCP · 2019Article
- Article
- CapC, a Novel Autotransporter and Virulence Factor of Campylobacter jejuni.Applied and environmental microbiology · 2018Article
- Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.PLoS neglected tropical diseases · 2017Article
- Article
- Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni.PLoS biology · 2017Article
- Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression.Scientific reports · 2017Article
- Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli.BMC microbiology · 2014Article
- A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni is a major cause of food-borne disease in industrialized countries. Carbohydrate utilization by C. jejuni is severely restricted, and knowledge about which substrates fuel C. jejuni infection and growth is limited. Some amino acids have been shown to serve as carbon sources both in vitro and in vivo. In the present study we investigated the contribution of serine and proline catabolism to the invitro and invivo growth of C. jejuni 81-176. We confirmed that the serine transporter SdaC and the serine ammonia-lyase SdaA are required for serine utilization, and demonstrated that a predicted proline permease PutP and a bifunctional proline/delta-1-pyrroline-5-carboxylate dehydrogenase PutA are required for proline utilization by C. jejuni 81-176. C. jejuni 81-176 mutants unable to utilize serine were shown to be severely defective for colonization of the intestine and systemic tissues in a mouse model of infection. In contrast, C. jejuni 81-176 mutants unable to utilize proline were only defective for intestinal colonization. These results further emphasize the importance of amino acid utilization in C. jejuni colonization of various tissues.
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