ArticlePloS one2012
Caspase-1 and IL-1β processing in a teleost fish.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- An ancient evolutionary origin for IL-1 cytokines.Nature ecology & evolution · 2026Article
- The caspase gene family in Micropterus salmoides: genome-wide characterization, bioinformatics, and expression profiling analysis.BMC genomics · 2026Article
- Sexual dimorphism in NLR transcripts and its downstream signaling protein IL-1ꞵ in teleost Channa punctata (Bloch, 1793).Scientific reports · 2024Article
- Effect of Copper Sulphate Exposure on the Oxidative Stress, Gill Transcriptome and External Microbiota of Yellow Catfish,Antioxidants (Basel, Switzerland) · 2023Article
- Article
- Teleost NOD-like receptors and their downstream signaling pathways: A brief review.Fish and shellfish immunology reports · 2022Review
- Revisiting the origin of interleukin 1 in anamniotes and sub-functionalization of interleukin 1 in amniotes.Open biology · 2022Article
- Chronic Inflammation Modulates Opioid Receptor Gene Expression and Triggers Respiratory Burst in a Teleost Model.Biology · 2022Article
- Short-Term Immune Responses of Gilthead Seabream (International journal of molecular sciences · 2022Article
- A Comparative Review of Pyroptosis in Mammals and Fish.Journal of inflammation research · 2022Review
- Comparative Study ofFrontiers in cellular and infection microbiology · 2022Article
- Transcriptome Analysis in the Head Kidney of Rainbow Trout (Vaccines · 2021Article
- Article
- Inflammasomes in Teleosts: Structures and Mechanisms That Induce Pyroptosis during Bacterial Infection.International journal of molecular sciences · 2021Review
- The round goby genome provides insights into mechanisms that may facilitate biological invasions.BMC biology · 2020Article
- The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis.The Journal of biological chemistry · 2020Article
- Interleukin-1 Ligands and Receptors in Lumpfish (Frontiers in immunology · 2020Article
- Molecular characterization and gene expression analysis of the pro-inflammatory cytokines IL-1β and IL-8 in the South American fish Piaractus mesopotamicus challenged with Aeromonas dhakensis.Genetics and molecular biology · 2020Article
- Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways.Cellular & molecular immunology · 2017Review
- Identification of an Evolutionarily Conserved Ankyrin Domain-Containing Protein, Caiap, Which Regulates Inflammasome-Dependent Resistance to Bacterial Infection.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukine-1β (IL-1β) is the most studied pro-inflammatory cytokine, playing a central role in the generation of systemic and local responses to infection, injury, and immunological challenges. In mammals, IL-1β is synthesized as an inactive 31 kDa precursor that is cleaved by caspase-1 generating a 17.5 kDa secreted active mature form. The caspase-1 cleavage site strictly conserved in all mammalian IL-1β sequences is absent in IL-1β sequences reported for non-mammalian vertebrates. Recently, fish caspase-1 orthologues have been identified in sea bass (Dicentrarchus labrax) and sea bream (Sparus aurata) but very little is known regarding their processing and activity. In this work it is shown that sea bass caspase-1 auto-processing is similar to that of the human enzyme, resulting in active p24/p10 and p20/p10 heterodimers. Moreover, the presence of alternatively spliced variants of caspase-1 in sea bass is reported. The existence of caspase-1 isoforms in fish and in mammals suggests that they have been evolutionarily maintained and therefore are likely to play a regulatory role in the inflammatory response, as shown for other caspases. Finally, it is shown that sea bass and avian IL-1β are specifically cleaved by caspase-1 at different but phylogenetically conserved aspartates, distinct from the cleavage site of mammalian IL-1β.
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Registered trials
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