ArticlePloS one2012
Different HCV genotype distributions of HIV-infected individuals in Henan and Guangxi, China.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- Distribution pattern, molecular transmission networks, and phylodynamic of hepatitis C virus in China.PloS one · 2023Article
- Distribution and changes in hepatitis C virus genotype in China from 2010 to 2020.World journal of clinical cases · 2022Article
- Review on the molecular epidemiology of sexually acquired hepatitis C virus infection in the Asia-Pacific region.Journal of the International AIDS Society · 2020Review
- Prevalence and genetic diversity of HCV among HIV-1 infected individuals living in Ahvaz, Iran.BMC infectious diseases · 2019Article
- Sequencing of hepatitis C virus for detection of resistance to direct-acting antiviral therapy: A systematic review.Hepatology communications · 2017Review
- Intravenous drug use - an independent predictor for HCV genotypes 3 and 4 infection among HIV/HCV co-infected patients.Archives of medical science : AMS · 2017Article
- Detection and analysis of hepatitis C virus in HIV-infected patients in the Guangxi province of China.Experimental and therapeutic medicine · 2017Article
- The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes.Advanced biomedical research · 2017Article
- Molecular epidemiology of hepatitis C infections in Ningxia, China: genotype, phylogeny and mutation analysis.Virology journal · 2016Article
- Article
- Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.PloS one · 2014Article
- Spatial analysis on hepatitis C virus infection in mainland China: from 2005 to 2011.PloS one · 2014Article
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to shared transmission routes, hepatitis C virus (HCV) infection is highly prevalent among people infected with human immunodeficiency virus (HIV). Highly active antiretroviral therapy (HAART) is associated with hepatotoxicity, leading to the negative effects on patients with HIV/HCV co-infection. In order to provide valuable information for HCV management in this particular population, we investigated the HCV genotypes in HIV-infected individuals from Henan and Guangxi, the two provinces with the most HIV-infected cases in China.
methodsIndividuals, who acquired HIV infection through various risk routes, were recruited from Henan and Guangxi. Test of antibodies against HCV (anti-HCV) was conducted, and detection of HCV RNA was performed by PCR amplification. HCV subtypes were determined by direct sequencing of amplicons, followed by phylogenetic analysis.
resultsWe recruited a total of 1,112 HIV-infected people in this present study. Anti-HCV was detected from 218 (50.1%) patients from Henan and 81 (12.0%) patients from Guangxi, respectively. The highest prevalence of HIV/HCV co-infection was observed from FBDs (former blood donors) (87.2%) in Henan and IDUs (intravenous drug users) (81.8%) in Guangxi, respectively. The seroprevalence rate of HCV among people with sexual contact was significantly higher in Henan than in Guangxi (18.7% vs. 3.5%, P<0.05). The positive rate of HCV RNA in Henan and Guangxi was 30.6% (133/435) and 11.2% (76/677), respectively. Moreover, we found that 20 anti-HCV negative samples were HCV positive by PCR amplification. HCV subtype 1b (52.7%) was predominant in Henan, followed by subtype 2a (41.9%). The most frequently detected subtypes in Guangxi were 6a (35.6%) and 3b (32.9%).
conclusionThe HCV genotype distributions were different in HIV-infected people from Henan and Guangxi. HIV/HCV co-infection was not only linked to the transmission routes, but also associated with the geographic position.
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