Trial reportPloS one2012
MRI evidence: acute mountain sickness is not associated with cerebral edema formation during simulated high altitude.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The Methodological Quality of Studies Investigating the Acute Effects of Exercise During Hypoxia Over the Past 40 years: A Systematic Review.Frontiers in physiology · 2022Pooled it
- Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs.The Cochrane database of systematic reviews · 2018Pooled it
- Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs.The Cochrane database of systematic reviews · 2017Pooled it
- Cerebral volumetric changes induced by prolonged hypoxic exposure and whole-body exercise.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- Altitude illnesses.Nature reviews. Disease primers · 2024Review
- Rapid altitude displacement induce zebrafish appearing acute high altitude illness symptoms.Heliyon · 2024Article
- Baseline Psychological Traits Contribute to Lake Louise Acute Mountain Sickness Score at High Altitude.High altitude medicine & biology · 2022Article
- Exposure to 16 h of normobaric hypoxia induces ionic edema in the healthy brain.Nature communications · 2021Article
- Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment.Journal of translational medicine · 2016Article
- Evidence for cerebral edema, cerebral perfusion, and intracranial pressure elevations in acute mountain sickness.Brain and behavior · 2016Article
- Multiparametric Magnetic Resonance Investigation of Brain Adaptations to 6 Days at 4350 m.Frontiers in physiology · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute mountain sickness (AMS) is a common condition among non-acclimatized individuals ascending to high altitude. However, the underlying mechanisms causing the symptoms of AMS are still unknown. It has been suggested that AMS is a mild form of high-altitude cerebral edema both sharing a common pathophysiological mechanism. We hypothesized that brain swelling and consequently AMS development is more pronounced when subjects exercise in hypoxia compared to resting conditions. Twenty males were studied before and after an eight hour passive (PHE) and active (plus exercise) hypoxic exposure (AHE) (F(i)O(2) = 11.0%, P(i)O(2)∼80 mmHg). Cerebral edema formation was investigated with a 1.5 Tesla magnetic resonance scanner and analyzed by voxel based morphometry (VBM), AMS was assessed using the Lake Louise Score. During PHE and AHE AMS was diagnosed in 50% and 70% of participants, respectively (p>0.05). While PHE slightly increased gray and white matter volume and the apparent diffusion coefficient, these changes were clearly more pronounced during AHE but were unrelated to AMS. In conclusion, our findings indicate that rest and especially exercise in normobaric hypoxia are associated with accumulation of water in the extracellular space, however independent of AMS development. Thus, it is suggested that AMS and HACE do not share a common pathophysiological mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.