Evidence map›Paper›PMID 23226153›Full record

ArticleFrontiers in genetics2012

Replaying the tape of life: quantification of the predictability of evolution.

Alexander E Lobkovsky, Eugene V Koonin

Abstract read
In one paragraph

Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Repeated genetic adaptation under demographic limits in kiwifruit.The Plant journal : for cell and molecular biology · 2026
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  10. Accumulation and maintenance of information in evolution.Proceedings of the National Academy of Sciences of the United States of America · 2022
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  16. Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Article
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  20. A mechanistic view of enzyme evolution.Protein science : a publication of the Protein Society · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander E LobkovskyNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD, USA.
Eugene V Koonin

Funding

Comparative Analysis Of Completely Sequenced GenomesZIALM000073 · NLM · NATIONAL LIBRARY OF MEDICINE · PI KOONIN, EUGENE V · 2009 to 2025
$43.1M
6 · The paper itself

Abstract

The question whether adaptation follows a deterministic route largely prescribed by the environment or can proceed along a large number of alternative trajectories has engaged extensive research over the recent years. Experimental evolution studies enabled by advances in high throughput techniques for genome sequencing and manipulation, along with increasingly detailed mathematical modeling of fitness landscapes, are beginning to allow quantitative exploration of the repeatability of evolutionary trajectories. It is becoming clear that evolutionary trajectories in static correlated fitness landscapes are substantially non-random but the relative contributions of determinism and stochasticity in the evolution of specific phenotypes strongly depend on the specific conditions, particularly the magnitude of the selective pressure and the number of available beneficial mutations.

Indexed as

divergence of trajectoriesevolutionary trajectoryfitness landscapepredictability of evolution

Identifiers

PMID23226153
PMCPMC3509945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.