ArticleFrontiers in neuroscience2012
Linking adult olfactory neurogenesis to social behavior.
Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Sustained Notch activation depletes adult neural stem cells and impairs cognitive function.Scientific reports · 2026Article
- Linking Adult Olfactory Neurogenesis to Social Reproductive Stimuli: Mechanisms and Functions.International journal of molecular sciences · 2024Review
- An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
- A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis.EMBO reports · 2022Article
- COVID-19 and Parkinson's disease: Defects in neurogenesis as the potential cause of olfactory system impairments and anosmia.Journal of chemical neuroanatomy · 2021Review
- Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis.International journal of molecular sciences · 2021Review
- Testosterone and Adult Neurogenesis.Biomolecules · 2020Review
- Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs.Neural plasticity · 2019Article
- CPEB4-Dependent Neonate-Born Granule Cells Are Required for Olfactory Discrimination.Frontiers in behavioral neuroscience · 2019Article
- Sex Steroids and Adult Neurogenesis in the Ventricular-Subventricular Zone.Frontiers in endocrinology · 2018Review
- Reactive Neuroblastosis in Huntington's Disease: A Putative Therapeutic Target for Striatal Regeneration in the Adult Brain.Frontiers in cellular neuroscience · 2018Article
- Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice.Frontiers in behavioral neuroscience · 2017Article
- Opposite-sex attraction in male mice requires testosterone-dependent regulation of adult olfactory bulb neurogenesis.Scientific reports · 2016Article
- Adult Neurogenesis 50 Years Later: Limits and Opportunities in Mammals.Frontiers in neuroscience · 2016Article
- The Role of Adult-Born Neurons in the Constantly Changing Olfactory Bulb Network.Neural plasticity · 2016Review
- Adult neurogenesis: beyond learning and memory.Annual review of psychology · 2015Review
- Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors.Frontiers in behavioral neuroscience · 2015Article
- Olfaction, navigation, and the origin of isocortex.Frontiers in neuroscience · 2015Article
- The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory.Frontiers in systems neuroscience · 2015Article
- Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IN THE ADULT BRAIN, NEW NEURONS ARE ADDED TO TWO BRAIN AREAS: the olfactory bulb (OB) and the hippocampus. Newly-generated neurons integrate into the preexisting circuits, bringing a set of unique properties, such as increased plasticity and responsiveness to stimuli. However, the functional implications of the constant addition of these neurons remain unclear, although they are believed to be important for learning and memory. The levels of neurogenesis are regulated by a variety of environmental factors, as well as during learning, suggesting that new neurons could be important for coping with changing environmental demands. Notably, neurogenesis has been shown to be physiologically regulated in relation to reproductive behavior: neurogenesis increases in female mice upon exposure to cues of the mating partners, during pregnancy and lactation, and in male mice upon exposure to their offspring. In this scenario, and because of the key contribution of olfaction to maternal behavior, we sought to investigate the contribution of adult-generated neurons in the olfactory system to maternal behavior and offspring recognition. To do so, we selectively disrupted neurogenesis in the olfactory pathway of female mice using focal irradiation. Disruption of adult neurogenesis in the OB did not affect maternal behavior, or the ability of female mice to discriminate familiar from unfamiliar pups. However, reduction of olfactory neurogenesis resulted in abnormal social interaction of female mice, specifically with male conspecifics. Because the olfactory system is crucial for sex recognition, we suggest that the abnormal interaction with males could result from the inability to detect or discriminate male-specific odors and could therefore have implications for the recognition of potential mating partners. Here, I review the results of our study and others, and discuss their implications for our understanding of the function of adult neurogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.