ArticleNeoplasia (New York, N.Y.)2012
Long-range transcriptome sequencing reveals cancer cell growth regulatory chimeric mRNA.
Article in Neoplasia (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- TTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity.Nature communications · 2026Article
- Chimeric RNAiScience · 2023Article
- A non-mutatedFrontiers in oncology · 2023Article
- Pattern recognition in the landscape of seemingly random chimeric transcripts.Computational and structural biotechnology journal · 2023Article
- Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Detection of novel and recurrent conjoined genes in non-Hodgkin B-cell lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2021Article
- The landscape of chimeric RNAs in non-diseased tissues and cells.Nucleic acids research · 2020Article
- Pharmacogenetic and pharmacogenomic discovery strategies.Cancer drug resistance (Alhambra, Calif.) · 2019Review
- Characterization of genetic aberrations in a single case of metastatic thymic adenocarcinoma.BMC cancer · 2017Article
- RE: HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer.Journal of the National Cancer Institute · 2016Article
- Recurrent chimeric fusion RNAs in non-cancer tissues and cells.Nucleic acids research · 2016Article
- Novel RNA variants in colorectal cancers.Oncotarget · 2015Article
- Article
- Gene and miRNA expression changes in squamous cell carcinoma of larynx and hypopharynx.Genes & cancer · 2015Article
- Tandem RNA chimeras contribute to transcriptome diversity in human population and are associated with intronic genetic variants.PloS one · 2014Article
- Cancer subclonal genetic architecture as a key to personalized medicine.Neoplasia (New York, N.Y.) · 2013Article
- Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing.Translational oncology · 2013Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
mRNA chimeras from chromosomal translocations often play a role as transforming oncogenes. However, cancer transcriptomes also contain mRNA chimeras that may play a role in tumor development, which arise as transcriptional or post-transcriptional events. To identify such chimeras, we developed a deterministic screening strategy for long-range sequence analysis. High-throughput, long-read sequencing was then performed on cDNA libraries from major tumor histotypes and corresponding normal tissues. These analyses led to the identification of 378 chimeras, with an unexpectedly high frequency of expression (≈2 x 10(-5) of all mRNA). Functional assays in breast and ovarian cancer cell lines showed that a large fraction of mRNA chimeras regulates cell replication. Strikingly, chimeras were shown to include both positive and negative regulators of cell growth, which functioned as such in a cell-type-specific manner. Replication-controlling chimeras were found to be expressed by most cancers from breast, ovary, colon, uterus, kidney, lung, and stomach, suggesting a widespread role in tumor development.
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Registered trials
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