ArticleInternational journal of nanomedicine2012
Heparin nanomodification improves biocompatibility and biomechanical stability of decellularized vascular scaffolds.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Advancements and Challenges in Tissue-Engineered Heart Valves: Integrating Biomechanics, Biomaterials, and Biomimetic Design for Functional Maturity.Biomimetics (Basel, Switzerland) · 2026Review
- The application of composite scaffold materials based on decellularized vascular matrix in tissue engineering: a review.Biomedical engineering online · 2023Review
- In-Vitro Endothelialization Assessment of Heparinized Bovine Pericardial Scaffold for Cardiovascular Application.Polymers · 2022Article
- Regulatory perspectives of combination products.Bioactive materials · 2022Review
- Current development of bovine jugular vein conduit for right ventricular outflow tract reconstruction.Frontiers in bioengineering and biotechnology · 2022Review
- Small Diameter Xenogeneic Extracellular Matrix Scaffolds for Vascular Applications.Tissue engineering. Part B, Reviews · 2020Review
- Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.Biomaterials · 2017Article
- A Biomimetic Heparinized Composite Silk-Based Vascular Scaffold with sustained Antithrombogenicity.Scientific reports · 2017Article
- Uric acid is associated with vascular dementia in Chinese population.Brain and behavior · 2017Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Biocompatibility and biomechanical stability are two of the main obstacles limiting the effectiveness of vascular scaffolds. To improve the biomechanical stability and biocompatibility of these scaffolds, we created a heparin-nanomodified acellular bovine jugular vein scaffold by alternating linkage of heparin and dihydroxy-iron via self-assembly. Features of the scaffold were evaluated in vitro and in vivo. Heparin was firmly linked to and formed nanoscale coatings around the fibers of the scaffold, and the amount of heparin linked was about 808 ± 86 μg/cm(2) (101 ± 11 USP/cm(2)) per assembly cycle. The scaffolds showed significantly strengthened biomechanical stability with sustained release of heparin for several weeks in vitro. Importantly, the modified scaffolds showed significantly reduced platelet adhesion, stimulated proliferation of endothelial cells in vitro, and reduced calcification in a subcutaneous implantation rat model in vivo. Heparin nanomodification improves the biocompatibility and biomechanical stability of vascular scaffolds.
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