Evidence map›Paper›PMID 23226013›Full record

Trial reportInternational journal of chronic obstructive pulmonary disease2012

Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease.

Richard K Albert, John Connett, Jeffrey L Curtis, Fernando J Martinez, Meilan K Han, Stephen C Lazarus, Prescott G Woodruff

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of chronic obstructive pulmonary disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Richard K AlbertMedicine Service, Denver Health and Department of Medicine, University of Colorado Denver, USA. ralbert@dhha.org
John Connett
Jeffrey L Curtis
Fernando J Martinez
Meilan K Han
Stephen C Lazarus
Prescott G Woodruff
University of Michigan–Ann Arbor · USUniversity of California, San Francisco · USUniversity of Colorado Denver · USUniversity of Minnesota · US

Funding

COPD Clinical Research Network - Data Coordinating CenterU10HL074424 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CONNETT, JOHN E · 2003 to 2011
$21.0M
Novel Strategies Targeting Acute Exacerbation of COPDU10HL074409 · NHLBI · DENVER HEALTH AND HOSPITAL AUTHORITY · PI ALBERT, RICHARD K · 2003 to 2007
$4.1M
COPD Exacerbations: Pharmacogenetic Approaches to TherapyU10HL074428 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WASHKO, GEORGE R · 2003 to 2007
$3.4M
UAB/BVAMC Clinical Center in COPDU10HL074418 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2003 to 2007
$3.3M
Strategies to Improve COPD ManagementU10HL074407 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI CASABURI, RICHARD · 2003 to 2007
$3.2M
COPD Clinical Research Network & Clinical Research Skills Core DevelopmentU10HL074408 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CRINER, GERARD J · 2004 to 2007
$2.7M
Drug therapy for preventing COPD exacerbationsU10HL074416 · NHLBI · MINNESOTA VETERANS RESEARCH INST · PI NIEWOEHNER, DENNIS E. · 2003 to 2007
$2.7M
Clinical Center-COPD Clinical Research NetworkU10HL074441 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHARF, STEVEN M · 2003 to 2006
$2.6M
COPD Clinical Research NetworkU10HL074431 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAZARUS, STEPHEN C · 2003 to 2006
$2.2M
Strategies to Prevent COPD ExacerbationU10HL074422 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTINEZ, FERNANDO J · 2004 to 2007
$2.0M
COPD Clinical Research NetworkU10HL074439 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCIURBA, FRANK · 2004 to 2007
$1.7M
NHLBI NIH HHS U10 HL074407NHLBI NIH HHS U10 HL074408NHLBI NIH HHS U10 HL074409NHLBI NIH HHS U10 HL074416NHLBI NIH HHS U10 HL074418NHLBI NIH HHS U10 HL074422NHLBI NIH HHS U10 HL074424NHLBI NIH HHS U10 HL074428NHLBI NIH HHS U10 HL074431NHLBI NIH HHS U10 HL074439NHLBI NIH HHS U10 HL074441
6 · The paper itself

Abstract

backgroundMannose-binding lectin is a collectin involved in host defense against infection. Whether mannose-binding lectin deficiency is associated with acute exacerbations of chronic obstructive pulmonary disease is debated.

methodsParticipants in a study designed to determine if azithromycin taken daily for one year decreased acute exacerbations had serum mannose-binding lectin concentrations measured at the time of enrollment.

resultsSamples were obtained from 1037 subjects (91%) in the trial. The prevalence of mannose-binding lectin deficiency ranged from 0.5% to 52.2%, depending on how deficiency was defined. No differences in the prevalence of deficiency were observed with respect to any demographic variable assessed, and no differences were observed in time to first exacerbation, rate of exacerbations, or percentage of subjects requiring hospitalization for exacerbations in those with deficiency versus those without, regardless of how deficiency was defined.

conclusionIn a large sample of subjects with chronic obstructive pulmonary disease selected for having an increased risk of experiencing an acute exacerbation of chronic obstructive pulmonary disease, only 1.9% had mannose-binding lectin concentrations below the normal range and we found no association between mannose-binding lectin concentrations and time to first acute exacerbation or frequency of acute exacerbations during one year of prospective follow-up.

Indexed as

AgedAnti-Bacterial AgentsAzithromycinBiomarkersDisease ProgressionDrug Administration ScheduleFemaleHospitalizationHumansMaleMannose-Binding LectinMiddle AgedProportional Hazards ModelsProspective StudiesPulmonary Disease, Chronic ObstructiveTime FactorsAnti-Bacterial AgentsAzithromycinBiomarkersMannose-Binding Lectinacute exacerbationsCOPDmannose-binding lectin

Identifiers

PMID23226013
PMCPMC3514010
OpenAlexW1611163070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.