ArticlePharmacognosy research2012
Comparative analysis on the effect of palm oil (Elaeis guineensis) in reducing cadmium and lead accumulation in liver of Wistar rats.
Article in Pharmacognosy research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 20 citations in OpenAlex.
- Kaempferol prevents cadmium chloride-induced liver damage by upregulating Nrf2 and suppressing NF-κB and keap1.Environmental science and pollution research international · 2022Article
- Kaempferol Protects Against Cadmium Chloride-Induced Memory Loss and Hippocampal Apoptosis by Increased Intracellular Glutathione Stores and Activation of PTEN/AMPK Induced Inhibition of Akt/mTOR Signaling.Neurochemical research · 2020Article
- A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration.Pharmacognosy research · 2014Article
- Investigation of effects of time of measurement and modes of administration on cadmium accumulation in rat liver under some medicinal plants food supplemented diet.Pharmacognosy research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPalm oil from Elaeis guineensis is an edible nutrient substance with anti-inflammatory and antioxidant properties. We examined its protective effect against lead (Pb) and cadmium (Cd) accumulation in the liver. MATERIALS AND
methods12% w/w of palm oil (PO) in rat chow concentrate was fed to rats exposed to Cd (200ppm) and Pb (100ppm) in drinking water at different feeding regimens. PO was administered either at the same time with the metals (group 2), post-treatment after exposure (group 3) or pre-treatment before exposure (group 4) for six weeks. The heavy metal accumulations in the liver were determined using AAS.
resultsWeight losses induced by these metals were significantly (P<0.05) reversed by PO administration. Analysis among the groups showed that post-treatment group had a significant (P<0.05) higher percentage protection to Cd, but same time treatment for Pb (P<0.05) when compared with other groups. The protective ability to PO was only significantly (P<0.05) increased for Pb at week 2, but showed a time-dependent significant (P<0.05) increase for Cd across all treatment regimens.
conclusionPO is beneficial in reducing metal accumulation in the liver and has a higher hepatoprotective effect to Cd compared to Pb at the selected doses by possibly affecting the processes of uptake, assimilation and elimination of these metals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.