ReviewThe Journal of experimental biology2013
Toxoplasma gondii infection and behaviour - location, location, location?
Review in The Journal of experimental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 4 syntheses or guidelines pooled it, 220 citations in OpenAlex.
- Relationship between Toxoplasma gondii infection and psychiatric disorders in Iran: A systematic review with meta-analysis.PloS one · 2023Pooled it
- The Association between Toxoplasma gondii Infection and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis.PloS one · 2019Pooled it
- Toxoplasma gondii infection and behavioral outcomes in humans: a systematic review.Parasitology research · 2018Pooled it
- Association between Toxoplasma gondii seropositivity and Alzheimer's disease: a case-control study.Parasitology research · 2026Article
- The role of parasite-produced dopamine in Toxoplasma gondii-altered host behaviour.Nature communications · 2025Article
- Wanting what hurts: D1 dopamine neuronal stimulation in CeA is sufficient to induce maladaptive attraction.Communications biology · 2025Article
- Article
- Low Tenacity ofMicroorganisms · 2025Article
- Effects of latent infection of Toxoplasma gondii strains with different genotypes on mouse behavior and brain transcripts.Parasites & vectors · 2025Article
- Toxoplasma gondii associated with psychotic symptom load and cortisol in severe mental illness.Schizophrenia (Heidelberg, Germany) · 2025Article
- Association of neurobiological and immune serum biomarkers with Toxoplasma gondii infection in patients with schizophrenia.Parasitology research · 2025Article
- Pregnant Women Chronically Infected byPathogens (Basel, Switzerland) · 2025Article
- Impact of Experimental Congenital Toxoplasmosis on the Thyroid Gland: Histopathological and Immunobiochemical Indices Assessment.Acta parasitologica · 2025Article
- Toxoplasma gondii, suicidal behaviour and suicide risk factors in US Veterans enrolled in mental health treatment.Folia parasitologica · 2025Article
- Association between latent toxoplasmosis and bipolar disorder: a case-control seroprevalence study.BMC infectious diseases · 2025Article
- Sexually aggressive behavior triggered by parasitic infection - how parasites can influence our personality.Frontiers in psychiatry · 2025Review
- Seroprevalence and risk factors associated with toxoplasmosis in nomadic, rural, and urban communities of northwestern Iran.Frontiers in public health · 2025Article
- Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection.Journal of neurochemistry · 2024Article
- A comprehensive assessment of toxoplasmosis and its dormant impact on psychotic disorders (Review).Biomedical reports · 2024Review
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Parasite location has been proposed as an important factor in the behavioural changes observed in rodents infected with the protozoan Toxoplasma gondii. During the chronic stages of infection, encysted parasites are found in the brain but it remains unclear whether the parasite has tropism for specific brain regions. Parasite tissue cysts are found in all brain areas with some, but not all, prior studies reporting higher numbers located in the amygdala and frontal cortex. A stochastic process of parasite location does not, however, seem to explain the distinct and often subtle changes observed in rodent behaviour. One factor that could contribute to the specific changes is increased dopamine production by T. gondii. Recently, it was found that cells encysted with parasites in the brains of experimentally infected rodents have high levels of dopamine and that the parasite encodes a tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of this neurotransmitter. A mechanism is proposed that could explain the behaviour changes due to parasite regulation of dopamine. This could have important implications for T. gondii infections in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.