Evidence map›Paper›PMID 23225358›Full record

ReviewNMR in biomedicine2013

Microencapsulated cell tracking.

Dian R Arifin, Dorota A Kedziorek, Yingli Fu, Kannie W Y Chan, Michael T McMahon, Clifford R Weiss, Dara L Kraitchman, Jeff W M Bulte

Open access · greenAbstract readReview
In one paragraph

Review in NMR in biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. In Vivo Imaging of Naked and Microencapsulated Islet Cell Transplantation.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  4. Frontiers in endocrinology · 2021
    Review
  5. Article
  6. Article
  7. Quantitative CT andMagma (New York, N.Y.) · 2019
    Article
  8. Article
  9. Review
  10. Review
  11. Noninvasive Tracking of Alginate-Microencapsulated Cells.Methods in molecular biology (Clifton, N.J.) · 2017
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Nanoimaging in cardiovascular diseases: Current state of the art.The Indian journal of medical research · 2015
    Review
  17. Article
  18. Article
  19. Seeing stem cells at work in vivo.Stem cell reviews and reports · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dian R ArifinRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dorota A Kedziorek
Yingli Fu
Kannie W Y Chan
Michael T McMahon
Clifford R Weiss
Dara L Kraitchman
Jeff W M Bulte
Johns Hopkins University · USJohns Hopkins Medicine · USKennedy Krieger Institute · US

Funding

JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
Multi-Color Exchange Transfer Imaging of Drug Delivery NanocarriersR01EB015031 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MCMAHON, MICHAEL T · 2011 to 2014
$2.4M
X-ray & MR-visible Microencapsulation of Allogeneic Arteriogenic Cell TherapeuticR33HL089029 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KRAITCHMAN, DARA L · 2009 to 2011
$2.1M
DIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH SensingR01EB012590 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MCMAHON, MICHAEL T · 2010 to 2013
$1.3M
MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet CellsR01EB007825 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2007 to 2008
$992k
X-ray & MR-visible Microencapsulation of Allogeneic Arteriogenic Cell TherapeuticR21HL089029 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KRAITCHMAN, DARA L · 2007 to 2008
$814k
NHLBI NIH HHS R21 HL089029NHLBI NIH HHS R33 HL089029NIBIB NIH HHS R01 EB007825NIBIB NIH HHS R01 EB012590NIBIB NIH HHS R01 EB015031NIDDK NIH HHS P30 DK079637
6 · The paper itself

Abstract

Microencapsulation of therapeutic cells has been widely pursued to achieve cellular immunoprotection following transplantation. Initial clinical studies have shown the potential of microencapsulation using semi-permeable alginate layers, but much needs to be learned about the optimal delivery route, in vivo pattern of engraftment, and microcapsule stability over time. In parallel with noninvasive imaging techniques for 'naked' (i.e. unencapsulated) cell tracking, microcapsules have now been endowed with contrast agents that can be visualized by (1) H MRI, (19) F MRI, X-ray/computed tomography and ultrasound imaging. By placing the contrast agent formulation in the extracellular space of the hydrogel, large amounts of contrast agents can be incorporated with negligible toxicity. This has led to a new generation of imaging biomaterials that can render cells visible with multiple imaging modalities.

Indexed as

AnimalsCapsulesCell TrackingContrast MediaDextransDrug CompoundingHumansMagnetic PhenomenaMagnetite NanoparticlesCapsulesContrast MediaDextransferumoxidesMagnetite Nanoparticles

Identifiers

PMID23225358
PMCPMC3655121
OpenAlexW2145410626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.