SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
Three adiponectin rs1501299G/T, rs822395A/C, and rs822396A/G polymorphisms and risk of cancer development: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of ADIPOQ and ADIPOR variants with risk of colorectal cancer: A meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Pooled it
- Causal relevance of circulating adiponectin with cancer: a meta-analysis implementing Mendelian randomization.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Five common haplotype-tagging variants of adiponectin (ADIPOQ) and cancer susceptibility: a meta-analysis.Genetic testing and molecular biomarkers · 2014Pooled it
- Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer.Pathology oncology research : POR · 2016Article
- Tumor expression of adiponectin receptor 2 and lethal prostate cancer.Carcinogenesis · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Many epidemiological studies have studied the associations between adiponectin rs1501299G/T, rs822395A/C, and rs822396A/G polymorphisms and risk of cancer development, while conflicting results have been reported. Therefore, we conducted a meta-analysis to assess the associations. We retrieved the following databases: Medline, Embase, Web of Science, and Wanfang, and the latest update date was 15th of August 2012. Odds ratio (OR) and corresponding 95 % confidence interval (95 % CI) were calculated by using fixed- or random-effect model. Overall, there were 13 case-control studies consisting of 7,902 subjects for adiponectin rs1501299G/T, seven studies consisting of 6,209 subjects for rs822395A/C, and seven studies consisting of 5,791 subjects for rs822396A/G polymorphism in this study. Combined analyses indicated that neither adiponectin rs822395A/C nor rs822396A/G was associated with risk of cancer incidence (OR (95 % CI) 0.91 (0.77-1.77), P z test = 0.26 for CC vs. AA and 0.96 (0.87-1.05) for C carriers vs. A carriers, P z test = 0.33 for rs822395A/C; 0.88 (0.53-1.47) for GG vs. AA, P z test = 0.63 and 0.94 (0.84-1.04) for G carriers vs. A carriers, P z test = 0.24 for rs822396A/G polymorphism). Similarly, combined analysis also indicated that adiponectin rs1501299G/T polymorphism was not associated with risk of cancer development (OR (95 % CI) 0.86 (0.73-1.01) for TT vs. GG, P z test = 0.07 and 1.17 (0.98-1.39), P z test = 0.08). However, when stratified analyses were conducted, the result indicated that T allele was significantly associated with increased cancer risk for Caucasians (OR (95 % CI) 1.28 (1.06-1.64) and P z test = 0.01 for G carriers vs. T carriers) and associated with increased risk of colorectal cancer development while with decreased risk of prostate cancer incidence compared to G allele (OR (95 % CI) 1.34 (1.14-1.57), P z test < 0.01 for G carriers vs. T carriers for colorectal cancer; 0.80 (0.65-0.97), P z test = 0.03 for TG vs. GG for prostate cancer). In summary, this meta-analysis indicated that adiponectin rs1501299G/T, rather than rs822395A/C and rs822396A/G polymorphism, was associated with risk of cancer development, especially for colorectal and prostate cancer.
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