Trial reportArchives of osteoporosis2012
Exercise effects on hip bone mineral density in older, post-menopausal breast cancer survivors are age dependent.
Trial report in Archives of osteoporosis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00591747 (Strength Training for Older Breast Cancer Survivors), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strength Training for Older Breast Cancer Survivors
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The effects of exercise interventions on bone mineral density in middle-aged and older men: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Pooled it
- Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018Pooled it
- Exercise for improving bone health in women treated for stages I-III breast cancer: a systematic review and meta-analyses.Journal of cancer survivorship : research and practice · 2017Pooled it
- Whole Body Vibration Exposure on Markers of Bone Turnover, Body Composition, and Physical Functioning in Breast Cancer Patients Receiving Aromatase Inhibitor Therapy: A Randomized Controlled Trial.Integrative cancer therapies · 2018Trial
- Results of the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial: A Behavioral Weight Loss Intervention in Overweight or Obese Breast Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Skeletal response to resistance and impact training in prostate cancer survivors.Medicine and science in sports and exercise · 2014Trial
- State of research, feasibility, safety, acceptability, and outcomes examined on remotely delivered exercises using technology for older adult with cancer: a scoping review.Journal of cancer survivorship : research and practice · 2024Article
- Time to consider the potential role of alternative resistance training methods in cancer management?Journal of sport and health science · 2023Review
- Fracture Risk Among Older Cancer Survivors Compared With Older Adults Without a History of Cancer.JAMA oncology · 2023Article
- Impact of physical exercise in cancer survivors during and after antineoplastic treatments.Oncotarget · 2018Review
- The Effects of Resistance Exercise on Biomarkers of Breast Cancer Prognosis: A Pooled Analysis of Three Randomized Trials.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Exercise Recommendations for the Management of Symptoms Clusters Resulting From Cancer and Cancer Treatments.Seminars in oncology nursing · 2016Review
- Cancer survivorship issues: life after treatment and implications for an aging population.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Review
- Whole body vibration exercises and the improvement of the flexibility in patient with metabolic syndrome.Rehabilitation research and practice · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledWe evaluated whether age moderated the effect of impact + resistance exercise on hip BMD in older post-menopausal breast cancer survivors (BCS). Exercise was more beneficial among younger than older women within our sample, suggesting that much older BCS may require different training programs to improve hip health. PURPOSE: Previously, we reported that a program of resistance + impact training stopped bone loss at the spine in older, post-menopausal BCS but had no effect on bone mineral density (BMD) at the hip. Aging may blunt the responsiveness of the hip to mechanical loading, so we conducted a secondary data analysis to evaluate whether age moderated the effect of exercise on hip BMD.
methodsWe analyzed data from our randomized, controlled trial in older (≥ 50 years of age at diagnosis), post-menopausal, post-adjuvant treatment BCS (n = 106) comparing women assigned to impact + resistance exercise (POWIR) or to a control program of low-intensity stretching (FLEX). We examined effect modification by age on BMD at three hip sites (greater trochanter, femoral neck, and total hip) using hierarchical linear modeling adjusting for time since diagnosis and use of adjuvant hormone therapy.
resultsAge moderated the effect of exercise on total hip BMD such that younger women in POWIR were more likely to see a positive net benefit than FLEX compared to older women where there was little difference between groups (p = 0.02).
conclusionsThe skeletal response to loading at the hip within post-menopausal BCS diminishes with age. Whether more vigorous exercise programs and/or longer training periods are required to favorably change hip health in older BCS will require future study and careful thought about the risks and benefits of tougher training programs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.