ArticleThe Journal of comparative neurology2013
Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-Cre transgenic mouse line.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells.Scientific reports · 2024Article
- A systematic comparison of optogenetic approaches to visual restoration.Molecular therapy. Methods & clinical development · 2022Article
- Tools and Biomarkers for the Study of Retinal Ganglion Cell Degeneration.International journal of molecular sciences · 2022Review
- Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina.Cell reports · 2021Article
- Spike-triggered Clustering for Retinal Ganglion Cell Classification.Experimental neurobiology · 2020Article
- The M6 cell: A small-field bistratified photosensitive retinal ganglion cell.The Journal of comparative neurology · 2019Article
- Opposing expression gradients of calcitonin-related polypeptide alpha (Calca/Cgrpα) and tyrosine hydroxylase (Th) in type II afferent neurons of the mouse cochlea.The Journal of comparative neurology · 2018Article
- Intersectional Strategies for Targeting Amacrine and Ganglion Cell Types in the Mouse Retina.Frontiers in neural circuits · 2018Article
- Organization of the dorsal lateral geniculate nucleus in the mouse.Visual neuroscience · 2017Review
- Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART).Peptides · 2016Article
- Article
- Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Genetically targeted binary labeling of retinal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice.PloS one · 2014Article
- Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing Cre transgenic mouse lines.Molecular vision · 2013Article
- rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo.PloS one · 2013Article
- Cell-specific cre recombinase expression allows selective ablation of glutamate receptors from mouse horizontal cells.PloS one · 2013Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Retinal ganglion cells are categorized into multiple classes, including multiple types of bistratified ganglion cells (BGCs). The recent use of transgenic mouse lines with specific type(s) of ganglion cells that are labeled by fluorescent markers has facilitated the morphological and physiological studies of BGCs, particularly the directional-selective BGCs. The most important benefit from using transgenic animals is the capability to perform in vivo gene manipulation. In particular, the Cre/LoxP recombination system has become a powerful tool, allowing gene deletion, overexpression, and ectopic expression in a cell type-specific and temporally controlled fashion. The key to this tool is the availability of Cre mouse lines with cell or tissue type-specific expression of Cre recombinase. In this study we characterized the Cre-positive retinal ganglion cells in a PCP2 (Purkinje cell protein 2)-cre mouse line. We found that all of the Cre-positive retinal ganglion cells were BGCs. Based on morphological criteria, we determined that they can be grouped into five types. The On- and Off-dendrites of three of these types stratified outside of the cholinergic bands and differed from directional selective ganglion cells (DSGCs) morphologically. These cells were negative for Brn-3b and positive for both calretinin and CART retina markers. The remaining two types were identified as putative On-Off and On-DSGCs. This Cre mouse line could be useful for further studies of the molecular and functional properties of BGCs in mice.
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