ArticleAnnals of surgical oncology2013
Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer.
Article in Annals of surgical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Radiation-induced angiosarcoma of the breast: individual participant meta-analysis of Japanese population.Breast cancer (Tokyo, Japan) · 2023Pooled it
- Primary and secondary breast angiosarcoma: single center report and a meta-analysis.Breast cancer research and treatment · 2019Pooled it
- Primary Breast Angiosarcoma: Clinicopathologic Features and Oncologic Outcomes.Annals of surgical oncology · 2026Article
- ASO Author Reflections: The Addition of Chemotherapy and Radiation to Surgery Improves Survival in Patients with Radiation-Associated Angiosarcoma of the Breast.Annals of surgical oncology · 2026Article
- Improved Oncologic Outcomes with Trimodality Therapy for Radiation-Associated Angiosarcoma of the Breast.Annals of surgical oncology · 2026Article
- Metachronous Double Primary Malignancies of Invasive Ductal Carcinoma of the Breast and Primary Ovarian Angiosarcoma.Iranian journal of pathology · 2026Article
- Clinical and prognostic insights into radiation-associated angiosarcoma: a multi-institutional analysis.Radiation oncology (London, England) · 2026Article
- Prognostic Factors and Outcomes for Post-Radiation Sarcoma-A Systematic Review and Meta-Analysis.Cancers · 2026Review
- Article
- Case Report: Metachronous bilateral primary and secondary angiosarcoma of the breast.Frontiers in oncology · 2026Article
- Secondary Lower-Body Sarcomas in Cervical Cancer Survivors Following Surgery, Radiotherapy, or Both: A Population-Based Study.Cancer science · 2026Article
- Angiosarcoma: a 10-year retrospective study from a high-volume UK regional referral centre.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Imaging Features of the Mesenchymal Tumors of the Breast according to WHO Classification: A Pictorial Essay.Journal of the Korean Society of Radiology · 2025Review
- Radiation-Associated Angiosarcoma of the Breast: The State of the Art of a Rare and Aggressive Disease.Journal of personalized medicine · 2024Review
- Risk of thoracic soft tissue sarcoma after breast cancer radiotherapy: a population-based cohort study in Osaka, Japan.Journal of radiation research · 2024Article
- Radiation-induced angiosarcoma of the breast: retrospective analysis at a regional treatment centre.Breast cancer (Tokyo, Japan) · 2024Article
- Angiosarcoma of gallbladder, a literature review.Journal of medical case reports · 2024Review
- Article
- Article
- Distinct genomic landscapes in radiation-associated angiosarcoma compared with other radiation-associated sarcoma histologies.The Journal of pathology · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRadiation-associated angiosarcoma (RAAS) is a devastating disease occasionally observed in breast cancer patients treated with radiation. Due to its rarity, our knowledge-of disease risk factors, epidemiology, treatment, and outcome-is extremely limited. Therefore, we sought to identify clinicopathologic factors associated with local and distant recurrence and disease-specific survival (DSS).
methodsRadiation-associated angiosarcoma was defined as pathologically confirmed breast or chest wall angiosarcoma arising within a previously irradiated field. A comprehensive search of our institutional tumor registry (1/1/93 through 2/28/11) was used to identify patients (n = 95 females). Patient, original tumor, RAAS treatment, and outcome variables were retrospectively retrieved and assembled into a database.
resultsThe median follow-up for all RAAS patients was 10.3 (range, 2.4-31.8) years. The latency period following radiation exposure ranged from 1.4 to 26 (median, 7) years. One-year and 5-year DSS rates were 93.5 and 62.6 %, respectively. Reduced risk of local recurrence was observed in patients who received chemotherapy (P = 0.0003). In multivariable analysis, size was found to be an independent predictor of adverse outcome (P = 0.015).
conclusionsOur study demonstrates that RAAS exhibits high recurrence rates. It also highlights the need for well-designed, multicenter, clinical trials to inform the true utility of chemotherapy in this disease.
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