ArticleNeurochemical research2013
Neonatal morphine administration leads to changes in hippocampal BDNF levels and antioxidant enzyme activity in the adult life of rats.
Article in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Analgosedation in Neonatal Intensive Care: Current Strategies, Challenges, and Future Perspectives.Life (Basel, Switzerland) · 2026Review
- Sex and dose differences in morphine administration on renal function, inflammatory and apoptotic markers in male and female Wistar rats.Current research in physiology · 2025Article
- 20- Deoxyingenol attenuate morphine-induced hippocampus neurotoxicity and memory impairments in rats.Heliyon · 2024Article
- Dysregulation of Vesicular Glutamate Transporter VGluT2Frontiers in pharmacology · 2022Article
- Exposure to Morphine and Caffeine Induces Apoptosis and Mitochondrial Dysfunction in a Neonatal Rat Brain.Frontiers in pediatrics · 2020Article
- Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers.Iranian journal of basic medical sciences · 2019Article
- Sedation and analgesia practices at Italian neonatal intensive care units: results from the EUROPAIN study.Italian journal of pediatrics · 2017Observational
- Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.Molecular pain · 2014Article
- Therapeutic concentration of morphine reduces oxidative stress in glioma cell line.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- Morphine protects against methylmercury intoxication: a role for opioid receptors in oxidative stress?PloS one · 2014Article
- Morphine as a Potential Oxidative Stress-Causing Agent.Mini-reviews in organic chemistry · 2013Article
- Pharmacoepidemiology of opiate use in the neonatal ICU: Increasing cumulative doses and iatrogenic opiate withdrawal.Journal of opioid managementArticle
- Differences in withdrawal symptoms, microglia activity, and cognitive functioning in rats exposed to continuous low-dose heroin in-utero.Neurotoxicology and teratologyArticle
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is know that repeated exposure to opiates impairs spatial learning and memory and that the hippocampus has important neuromodulatory effects after drug exposure and withdrawal symptoms. Thus, the aim of this investigation was to assess hippocampal levels of BDNF, oxidative stress markers associated with cell viability, and TNF-α in the short, medium and long term after repeated morphine treatment in early life. Newborn male Wistar rats received subcutaneous injections of morphine (morphine group) or saline (control group), 5 μg in the mid-scapular area, starting on postnatal day 8 (P8), once daily for 7 days, and neurochemical parameters were assessed in the hippocampus on postnatal days 16 (P16), 30 (P30), and 60 (P60). For the first time, we observed that morphine treatment in early life modulates BDNF levels in the medium and long term and also modulates superoxide dismutase activity in the long term. In addition, it was observed effect of treatment and age in TNF-α levels, and no effects in lactate dehydrogenase levels, or cell viability. These findings show that repeated morphine treatment in the neonatal period can lead to long-lasting neurochemical changes in the hippocampus of male rats, and indicate the importance of cellular and intracellular adaptations in the hippocampus after early-life opioid exposure to tolerance, withdrawal and addiction.
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