ReviewJournal of thrombosis and thrombolysis2013
Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer's disease.
Review in Journal of thrombosis and thrombolysis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Association between malnutrition and hyperhomocysteine in Alzheimer's disease patients and diet intervention of betaine.Journal of clinical laboratory analysis · 2017Trial
- Nutritional intervention for diabetes mellitus with Alzheimer's disease.Frontiers in nutrition · 2022Review
- Pleural biomarkers in diagnostics of malignant pleural effusion: a narrative review.Translational lung cancer research · 2021Review
- Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose.Metabolic brain disease · 2021Article
- Relationship between homocysteine level and prognosis of elderly patients with acute ischemic stroke treated by thrombolysis with recombinant tissue plasminogen activator.World journal of clinical cases · 2019Article
- Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S-sulfhydration in ApoE-knockout atherosclerotic mice.British journal of pharmacology · 2019Article
- Caffeine Prevents Memory Impairment Induced by Hyperhomocysteinemia.Journal of molecular neuroscience : MN · 2018Article
- Methylenetetrahydrofolate reductase C677T variant and hyperhomocysteinemia in subarachnoid hemorrhage patients from India.Metabolic brain disease · 2018Article
- Correlation of hippocampal atrophy with hyperhomocysteinemia in hemodialysis patients: An exploratory pilot study.PloS one · 2017Article
- Correlation between secondary thrombosis in epileptic patients and serum levels of folate and vitamin B12.Biomedical reports · 2016Article
- Alzheimer's disease patient groups derived from a multivariate analysis of cognitive test outcomes in the Coalition Against Major Diseases dataset.Future science OA · 2016Article
- The involvement of homocysteine in stress-induced Aβ precursor protein misprocessing and related cognitive decline in rats.Cell stress & chaperones · 2016Article
- Association between serum non-high-density lipoprotein cholesterol and cognitive impairment in patients with acute ischemic stroke.BMC neurology · 2016Article
- Folic Acid Protected Neural Cells Against Aluminum-Maltolate-Induced Apoptosis by Preventing miR-19 Downregulation.Neurochemical research · 2016Article
- Adropin is associated with hyperhomocysteine and coronary atherosclerosis.Experimental and therapeutic medicine · 2016Article
- Microvascular Dysfunction and Cognitive Impairment.Cellular and molecular neurobiology · 2016Review
- The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015Review
- Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against homocysteine-induced impairments in rat caudate nucleus through CB1 receptor.Journal of molecular neuroscience : MN · 2015Article
- The role of folic acid on the hyperhomocysteinemia in the Buerger's disease (Thromboangiitis Obliterans).Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Metformin Eased Cognitive Impairment Induced by Chronic L-methionine Administration: Potential Role of Oxidative Stress.Current neuropharmacology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inheired or acquired hyperhomocysteinemia (HHcy) is associated with several impairments, as certain tumors, deep venous thrombosis, tube neural defects, osteoporosis, early atherosclerosis and vascular acute events (IMA, stroke, PVD), mild cognitive impairments till Alzheimer's disease (AD). But, vascular and neuronal derangements are the most frequent HHcy-manifestations. As far as early atherosclerosis, some clinical trials demonstrated that folates and B6-12 vitamins supplementation is unable to reduce atherosclerotic lesions and cardiovascular events, even if it lowers HHcy levels. Thus, for atherosclerosis and its acute events (IMA, stroke, PVD) HHcy acts as a powerful biomarker rather than a risk factor. For that, the supplementation with folates and B vitamins to lower atherosclerotic lesions-events in hyperhomocysteinemic patients is not recommended. On the contrary, several clinical investigations demonstrated that folates and vitamins administration is able to reduce Hcy serum levels and antagonize some mechanisms favouring neurodegenerative impairments, as mild cognitive impairment, AD and dementia. Thus, contrarily to the atherosclerotic manifestations in hyperhomocysteinemic patients, preventive treatment with folates and B6-12 vitamins reduces Hcy concentration and could prevent or delay cognitive decline and AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.