ArticleNeurotoxicity research2013
Late anxiety-like behavior and neuroinflammation in mice subjected to sublethal polymicrobial sepsis.
Article in Neurotoxicity research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- What Animal Models Can Tell Us About Long-Term Psychiatric Symptoms in Sepsis Survivors: a Systematic Review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Pooled it
- Lipocalin-2 perpetuates postoperative and post-infectious neuroinflammation and anxiety-like behavior.Brain, behavior, and immunity · 2026Article
- Extracellular Histones Associate with Blood-Brain Barrier Disruption and Astrocyte-Mediated Neuroinflammation During Polymicrobial Sepsis.International journal of molecular sciences · 2026Article
- The Impact of Biological Sex And High-Fat High-Fructose Diet on Brain Dysfunction in an Animal Model of Sepsis.Molecular neurobiology · 2025Article
- Lung-brain crosstalk: Behavioral disorders and neuroinflammation in septic survivor mice.Brain, behavior, & immunity - health · 2024Article
- Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Article
- AQP4 Aggravates Cognitive Impairment in Sepsis-Associated Encephalopathy through Inhibiting NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-CaJournal of neuroinflammation · 2022Article
- Silencing of amygdala circuits during sepsis prevents the development of anxiety-related behaviours.Brain : a journal of neurology · 2022Article
- Neuronal MD2 induces long-term mental impairments in septic mice by facilitating necroptosis and apoptosis.Frontiers in pharmacology · 2022Article
- Neuroinflammation in Sepsis: Molecular Pathways of Microglia Activation.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The Neuroprotective Effect of Short Chain Fatty Acids Against Sepsis-Associated Encephalopathy in Mice.Frontiers in immunology · 2021Article
- Simvastatin Prevents Long-Term Cognitive Deficits in Sepsis Survivor Rats by Reducing Neuroinflammation and Neurodegeneration.Neurotoxicity research · 2020Article
- Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction.Psychoneuroendocrinology · 2020Article
- Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus.Scientific reports · 2017Article
- Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism.Scientific reports · 2017Article
- Preclinical models of overwhelming sepsis implicate the neural system that encodes contextual fear memory.Molecular medicine (Cambridge, Mass.) · 2016Article
- Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation.PloS one · 2016Article
- Does prior sepsis alter subsequent circadian and sickness behaviour response to lipopolysaccharide treatment in mice?Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis can lead to long-term cognitive changes, including memory and learning deficits, which are known as septic encephalopathy (SE). SE also includes behavioral changes. The underlying mechanism of SE is unknown, and several mechanisms have been proposed. This study investigated late anxiety-like behavior, serum cytokine levels and brain cytokine production in C57BL/6 mice subjected to polymicrobial sepsis induced by sublethal cecum ligature and puncture (CLP). Anxiety-like behavior and locomotor activity were assessed in mice 10 days after sham operation or CLP procedure using the elevated plus maze, contextual fear conditioning, and open field test. Brain and serum concentrations of the cytokines TNF-α, IFN-γ, IL-1β, IL-6, and IL-10 were determined by ELISA. We found that mice subjected to polymicrobial sepsis presented anxiety-like behavior, which was accompanied by increased serum TNF-α and brain TNF-α, IFN-γ, IL-1β, and IL-6 levels, 10 days after the surgical procedure. These findings suggest an involvement of central nervous system inflammatory mediators in the anxiety-like symptoms found in SE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.