ArticleMolecular biology reports2013
Disruption of the transcription factor RBP-J results in osteopenia attributable to attenuated osteoclast differentiation.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Intrinsic Restriction of TNF-Mediated Inflammatory Osteoclastogenesis and Bone Resorption.Frontiers in endocrinology · 2020Review
- Strontium inhibits osteoclastogenesis by enhancing LRP6 and β-catenin-mediated OPG targeted by miR-181d-5p.Journal of cell communication and signaling · 2019Article
- Lipoteichoic acid of Enterococcus faecalis inhibits osteoclastogenesis via transcription factor RBP-J.Innate immunity · 2019Article
- Article
- C/EBPα transcription factor is regulated by the RANK cytoplasmicThe Journal of biological chemistry · 2018Article
- Does TNF Promote or Restrain Osteoclastogenesis and Inflammatory Bone Resorption?Critical reviews in immunology · 2018Review
- NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.Scientific reports · 2017Article
- The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- TNF and Bone Remodeling.Current osteoporosis reports · 2017Review
- Stimulation of Notch Signaling in Mouse Osteoclast Precursors.Journal of visualized experiments : JoVE · 2017Article
- RIG-I-Like Receptor Signaling in Singleton-Merten Syndrome.Frontiers in genetics · 2017Review
- Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- High bone mass in mice lacking Cx37 because of defective osteoclast differentiation.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor recombination signal binding protein-Jκ (RBP-J) is the critical transcription factor downstream to all four mammalian Notch receptors. Although it has been reported that Notch signaling pathway is involved in bone remodeling, the importance of RBP-J in osteoclastogenesis has not been fully explored. To investigate the role of RBP-J in osteoclastogenesis, we conditionally deleted RBP-J systemically in bone marrow (BM) or specifically in macrophages. We found that disruption of RBP-J in BM resulted in an obvious decrease in trabecular bone mass associated with an increase in osteoclasts, leading to osteopenia. Disruption of RBP-J in macrophages phenocopied the phenotypes of RBP-J deletion in BM with respect to osteoclastogenesis, suggesting that the osteopenia in RBP-J deficient mice is essentially resulted from increased osteoclastogenesis. Furthermore, we found that RBP-J deletion in osteoclasts resulted in a dramatic increase in tartrate-resistant acid phosphatase expression. These findings demonstrate a negatively role of RBP-J in the differentiation of osteoclasts and suggest that Notch pathway may be a new therapeutic target for bone diseases related to increased osteoclastogenesis.
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