ArticleMolecular biology reports2013
The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Targeting menin in lysine methyltransferase 2A/nucleophosmin-mutated leukemia: A novel strategy from epigenetic dysregulation to clinical therapy (Review).Oncology letters · 2025Review
- A neural substrate of comorbid depressive symptoms in alcohol use.Molecular psychiatry · 2025Article
- Menin: from molecular insights to clinical impact.Epigenomics · 2025Review
- Menin in Cancer.Genes · 2024Review
- Menin orchestrates hepatic glucose and fatty acid uptake via deploying the cellular translocation of SIRT1 and PPARγ.Cell & bioscience · 2023Article
- Menin Enhances Androgen Receptor-Independent Proliferation and Migration of Prostate Cancer Cells.Molecules and cells · 2022Article
- Chitosan nanoparticle-mediated effect of antimiRNA-324-5p on decreasing the ovarian cancer cell proliferation by regulation of GLI1 expression.BioImpacts : BI · 2022Article
- Role of miR-24 in Multiple Endocrine Neoplasia Type 1: A Potential Target for Molecular Therapy.International journal of molecular sciences · 2021Review
- Article
- Characterization of molecular signatures of supratentorial ependymomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Wild-type menin is rapidly degraded via the ubiquitin-proteasome pathway in a rat insulinoma cell line.Bioscience reports · 2019Article
- The future: genetics advances in MEN1 therapeutic approaches and management strategies.Endocrine-related cancer · 2017Review
- Epigenetic regulation by the menin pathway.Endocrine-related cancer · 2017Review
- Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.Oncotarget · 2017Article
- A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.Gene expression · 2017Review
- miR-24 Inhibition Increases Menin Expression and Decreases Cholangiocarcinoma Proliferation.The American journal of pathology · 2017Article
- High expression of Snail and NF-κB predicts poor survival in Chinese hepatocellular carcinoma patients.Oncotarget · 2017Article
- Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Article
- MicroRNA-142-3p, a novel target of tumor suppressor menin, inhibits osteosarcoma cell proliferation by down-regulation of FASN.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncogenic activation of the NF-κB signaling pathway is common in hepatocellular carcinoma (HCC). However, the molecular mechanisms remain largely unexplored. Previous studies have demonstrated that menin, a tumor suppressor protein, could interact with NF-κB protein and repress p65-mediated transcriptional activation. In the present study, we found that expression of menin was frequently down-regulated in HCC tissues and cells. Furthermore, menin could repress p65 acetylation through recruitment of Sirt1, an enzyme that deacetylases p65 in lysine 310 (K310). Indeed, Sirt1 inhibitor or its specific small interfering RNA abolished the inhibitory roles of menin. Together, these observations suggest that the interaction between menin and Sirt1 is required for the tumor suppressor function of menin in HCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.