ArticleJournal of biomedical optics2012
Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function.
Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage.Nature aging · 2024Article
- Dynamic multispectral NIR/SWIR forJournal of biomedical optics · 2024Article
- Development and application of a novel cervical lymph collection method to assess lymphatic transport in rats.Frontiers in pharmacology · 2023Article
- Improving obesity and lipid metabolism using conjugated linoleic acid.Veterinary medicine and science · 2022Article
- Vmeasur: A software package for experimental and clinical measurement of mesenteric lymphatic contractile function over an extended vessel length.Microcirculation (New York, N.Y. : 1994) · 2022Article
- Fluorescent Tracers forFrontiers in pharmacology · 2022Review
- Characterization of rat tail lymphatic contractility and biomechanics: incorporating nitric oxide-mediated vasoregulation.Journal of the Royal Society, Interface · 2020Article
- Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans.Frontiers in physiology · 2020Article
- Age-related changes in B cell metabolism.Aging · 2019Article
- Emerging Role of Lymphatics in the Regulation of Intestinal Lipid Mobilization.Frontiers in physiology · 2019Review
- High-speed microscopy for in vivo monitoring of lymph dynamics.Journal of biophotonics · 2018Article
- Differences in L-type CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- The relationship between lymphangion chain length and maximum pressure generation established through in vivo imaging and computational modeling.American journal of physiology. Heart and circulatory physiology · 2017Article
- Experimental Models Used to Assess Lymphatic Contractile Function.Lymphatic research and biology · 2017Review
- Lipid-associated oral delivery: Mechanisms and analysis of oral absorption enhancement.Journal of controlled release : official journal of the Controlled Release Society · 2016Review
- Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Microparticle image velocimetry approach to flow measurements in isolated contracting lymphatic vessels.Journal of biomedical optics · 2016Article
- Dextran sulfate sodium-induced acute colitis impairs dermal lymphatic function in mice.World journal of gastroenterology · 2015Article
- Intravital imaging of intestinal lacteals unveils lipid drainage through contractility.The Journal of clinical investigation · 2015Article
- Effects of dynamic shear and transmural pressure on wall shear stress sensitivity in collecting lymphatic vessels.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Nearly all dietary lipids are transported from the intestine to venous circulation through the lymphatic system, yet the mechanisms that regulate this process remain unclear. Elucidating the mechanisms involved in the functional response of lymphatics to changes in lipid load would provide valuable insight into recent implications of lymphatic dysfunction in lipid related diseases. Therefore, we sought to develop an in situ imaging system to quantify and correlate lymphatic function as it relates to lipid transport. The imaging platform provides the capability of dual-channel imaging of both high-speed bright-field video and fluorescence simultaneously. Utilizing post-acquisition image processing algorithms, we can quantify correlations between vessel pump function, lymph flow, and lipid concentration of mesenteric lymphatic vessels in situ. All image analysis is automated with customized LabVIEW virtual instruments; local flow is measured through lymphocyte velocity tracking, vessel contraction through measurements of the vessel wall displacement, and lipid uptake through fluorescence intensity tracking of an orally administered fluorescently labelled fatty acid analogue, BODIPY FL C16. This system will prove to be an invaluable tool for scientists studying intestinal lymphatic function in health and disease, and those investigating strategies for targeting the lymphatics with orally delivered drugs to avoid first pass metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.