ArticleJournal of biomedical optics2012
Effects of acetic acid on light scattering from cells.
Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Is age a determinant in cervical cancer screening in women aged 18 to 29?: An observational study.Medicine · 2025Observational
- Human Papillomavirus and Other Relevant Issues in Cervical Cancer Pathogenesis.International journal of molecular sciences · 2025Review
- Acetic acid enabled nuclear contrast enhancement in epi-mode quantitative phase imaging.Journal of biomedical optics · 2025Article
- Evolution of Pathological Techniques for the Screening of Cervical Cancer: A Comprehensive Review.Cureus · 2024Review
- Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology.Life (Basel, Switzerland) · 2023Article
- Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma.Cell systems · 2021Article
- Acetic Acid and Iodine Staining for Determining Malignancy in Solid Tumors.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Detection of precancerous lesions in the oral cavity using oblique polarized reflectance spectroscopy: a clinical feasibility study.Journal of biomedical optics · 2017Article
- Colposcopic Characteristics and Lugol's Staining Differentiate Anal High-Grade and Low-Grade Squamous Intraepithelial Lesions During High Resolution Anoscopy.Papillomavirus research (Amsterdam, Netherlands) · 2015Article
- HPV Carcinomas in Immunocompromised Patients.Journal of clinical medicine · 2015Review
- Effect of acetic acid on optical coherence tomography (OCT) images of cervical epithelium.Lasers in medical science · 2014Article
- Home Remedies in Dermatology.Indian dermatology online journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Acetic acid has been used for decades as an aid for the detection of precancerous cervical lesions, and the use of acetic acid is being investigated in several other tissues. Nonetheless, the mechanism of acetowhitening is unclear. This work tests some of the hypotheses in the literature and measures changes in light scattering specific to the nucleus and the cytoplasm. Wide angle side scattering from both the nucleus and the cytoplasm increases with acetic application to tumorigenic cells, with the increase in nuclear scattering being greater. In one cell line, the changes in nuclear scattering are likely due to an increase in number or scattering efficiency of scattering centers smaller than the wavelength of excitation light. There are likely several cellular changes that cause acetowhitening and the cellular changes may differ with cell type. These results should lead to a better understanding of acetowhitening and potentially the development of adjunct techniques to improve the utility of acetic acid application. For the well-studied case of cervical tissue, acetowhitening has been shown to be sensitive, but not specific for oncogenic changes needing treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.