ReviewInternational urogynecology journal2013
Injectable biomaterials for the treatment of stress urinary incontinence: their potential and pitfalls as urethral bulking agents.
Review in International urogynecology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence.The Cochrane database of systematic reviews · 2022Pooled it
- Comparison of synthetic mesh erosion and chronic pain rates after surgery for pelvic organ prolapse and stress urinary incontinence: a systematic review.International urogynecology journal · 2021Pooled it
- Polyacrylamide hydrogel (Bulkamid®) for stress urinary incontinence in women: a systematic review of the literature.International urogynecology journal · 2016Pooled it
- The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review.Clinics (Sao Paulo, Brazil) · 2016Pooled it
- Porcine-derived materials in urology Practical ethical guidance for caring for Muslim and Jewish patients.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Review
- Therapies Based on Adipose-Derived Stem Cells for Lower Urinary Tract Dysfunction: A Narrative Review.Pharmaceutics · 2022Review
- In-vitro cellular and in-vivo investigation of ascorbic acid and β-glycerophosphate loaded gelatin/sodium alginate injectable hydrogels for urinary incontinence treatment.Progress in biomaterials · 2021Article
- Individualized pelvic physical therapy for the treatment of post-prostatectomy stress urinary incontinence and pelvic pain.International urology and nephrology · 2020Article
- Regenerative medicine and injection therapies in stress urinary incontinence.Nature reviews. Urology · 2020Review
- Regenerative potential of human dental pulp stem cells in the treatment of stress urinary incontinence: In vitro and in vivo study.Cell proliferation · 2019Article
- Polydimethylsiloxane Erosion as a Cause for Recurrent Urinary Tract Infections.Journal of endourology case reports · 2019Article
- Contemporary diagnostics and treatment options for female stress urinary incontinence.Asian journal of urology · 2018Review
- Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions.Investigative and clinical urology · 2018Article
- Stress urinary incontinence in women: Current and emerging therapeutic options.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2017Review
- Treatment of Stress Urinary Incontinence in Neurological Patients With an Injectable Elastomer Prosthesis: Preliminary Results.International neurourology journal · 2017Article
- Effects of laser procedure for female urodynamic stress incontinence on pad weight, urodynamics, and sexual function.International urogynecology journal · 2017Article
- Para-Urethral Injections with Urolastic® for Treatment of Female Stress Urinary Incontinence: Subjective Improvement and Safety.Urologia internationalis · 2017Article
- Quality of life outcomes in peri-urethral calcium hydroxylapatite injection.International urogynecology journal · 2016Article
- Urolastic for the treatment of women with stress urinary incontinence: 24-month follow-up.Central European journal of urology · 2015Article
- Dual growth factor-loaded in situ gel-forming bulking agent: passive and bioactive effects for the treatment of urinary incontinence.Journal of materials science. Materials in medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injectable urethral bulking agents composed of synthetic and biological biomaterials are minimally invasive treatment options for stress urinary incontinence (SUI). The development of an ideal urethral bulking agent remains challenging because of clinical concerns over biocompatibility and durability. Herein, the mechanical and biological features of injectable urethral biomaterials are investigated, with particular emphasis on their future potential as primary and secondary treatment options for SUI. A literature search for English language publications using the two online databases was performed. Keywords included "stress urinary incontinence", "urethral bulking agent" and "injectable biomaterial". A total of 98 articles were analysed, of which 45 were suitable for review based on clinical relevance and importance of content. Injectable biomaterials are associated with a lower cure rate and fewer postoperative complications than open surgery for SUI. They are frequently reserved as secondary treatment options for patients unwilling or medically unfit to undergo surgery. Glutaraldehyde cross-linked bovine collagen remains the most commonly injected biomaterial and has a cure rate of up to 53 %. Important clinical features of an injectable biomaterial are durability, biocompatibility and ease of administration, but achieving these requirements is challenging. In carefully selected patients, injectable biomaterials are feasible alternatives to open surgical procedures as primary and secondary treatment options for SUI. In future, higher cure rates may be feasible as researchers investigate alternative biomaterials and more targeted injection techniques for treating SUI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.