Evidence map›Paper›PMID 23223630›Full record

ReviewPhysiology (Bethesda, Md.)2012

A role for A-to-I RNA editing in temperature adaptation.

Sandra C Garrett, Joshua J C Rosenthal

Open access · greenAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  6. Loss of CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Review
  8. Article
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  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. A-to-I RNA editing is developmentally regulated and generally adaptive for sexual reproduction inProceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  17. Article
  18. Article
  19. How nontraditional model systems can save us.Molecular biology of the cell · 2015
    Article
  20. The emerging role of RNA editing in plasticity.The Journal of experimental biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sandra C GarrettInstitute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. sandracoralgarrett@gmail.com
Joshua J C Rosenthal
University of Puerto Rico, Medical Sciences Campus · PR

Funding

SUPPLEMENT FOR RENOVATION OF ANIMAL FACILITIES AT INSTITUTE OF NEUROBIOLOGYG12RR003051 · NCRR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 1986 to 2011
$28.1M
SPECIALIZED PROGRAMS IN CELLULAR/ MOLECULAR NEUROBIOLOGYU54NS039405 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FRONTERA, WALTER R. · 1999 to 2011
$12.9M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Regulation of the Na/K Pump by RNA EditingR01NS064259 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ROSENTHAL, JOSHUA J.C. · 2010 to 2014
$1.5M
NCRR NIH HHS 2G12 RR-003051NCRR NIH HHS G12 RR003051NIMHD NIH HHS 8G12 MD-007600NIMHD NIH HHS G12 MD007600NINDS NIH HHS 2 U54 NS-039405-06NINDS NIH HHS R01 NS-064259NINDS NIH HHS R01 NS064259NINDS NIH HHS U54 NS039405PHS HHS FNS-064774A
6 · The paper itself

Abstract

A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.

Indexed as

RNA EditingAdaptation, BiologicalAnimalsHumansProtein IsoformsRNA, MessengerTemperatureProtein IsoformsRNA, Messenger

Identifiers

PMID23223630
PMCPMC4208822
OpenAlexW2163788272

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.