Evidence map›Paper›PMID 23223620›Full record

ArticleThe Journal of general virology2013

Upregulation of special AT-rich-binding protein 1 by Epstein-Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer.

Kazuhira Endo, Julia Shackelford, Mitsuharu Aga, Tomokazu Yoshizaki, Joseph S Pagano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma.Laboratory investigation; a journal of technical methods and pathology · 2019
    Article
  4. Review
  5. Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1 expression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  6. SATB1 and 2 in colorectal cancer.Carcinogenesis · 2015
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kazuhira EndoDivision of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, 920-8641, Japan.
Julia ShackelfordLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
Mitsuharu AgaDivision of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, 920-8641, Japan.
Tomokazu YoshizakiDivision of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, 920-8641, Japan.
Joseph S PaganoLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
UNC Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel Hill · USKanazawa University · JP

Funding

Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Dirk P Dittmer · 1985 to 2026
$43.8M
NCI NIH HHS P01 CA019014
6 · The paper itself

Abstract

A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines. Silencing of endogenously expressed SATB1 with specific short hairpin RNA decreases cell proliferation and resistance to apoptosis induced by growth factor withdrawal. Additionally, we provide evidence that LMP1-mediated expression of Survivin, a multifunctional protein involved in promoting cell growth and survival, is mediated at least in part by SATB1 in human nasopharyngeal cells. Finally, we show that SATB1 protein levels are elevated in tissue samples from patients with nasopharyngeal carcinoma (NPC), and are directly correlated with the expression of LMP1. Taken together, our results suggest that SATB1 functions as a pro-metastatic effector of LMP1 signalling in EBV-positive NPC.

Indexed as

CarcinomaCell LineCell ProliferationGene Expression RegulationHerpesvirus 4, HumanHumansMatrix Attachment Region Binding ProteinsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNosePharynxRNA, Small InterferingSignal TransductionViral Matrix ProteinsEBV-associated membrane antigen, Epstein-Barr virusMatrix Attachment Region Binding ProteinsRNA, Small InterferingSATB1 protein, humanViral Matrix Proteins

Identifiers

PMID23223620
PMCPMC3709608
OpenAlexW2029287543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.