ArticleMolecular biology of the cell2013
A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- IndividualLife science alliance · 2026Article
- Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning.Cell genomics · 2024Article
- KLP-7/Kinesin-13 orchestrates axon-dendrite checkpoints for polarized trafficking in neurons.Molecular biology of the cell · 2024Article
- Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties.Communications biology · 2024Article
- Article
- The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1.PLoS genetics · 2022Article
- Synaptic branch stability is mediated by non-enzymatic functions of MEC-17/αTAT1 and ATAT-2.Scientific reports · 2022Article
- Wnt signaling establishes the microtubule polarity in neurons through regulation of Kinesin-13.The Journal of cell biology · 2021Article
- Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration.Nature communications · 2020Article
- Diapause induces functional axonal regeneration after necrotic insult in C. elegans.PLoS genetics · 2019Article
- CAMSAP3 maintains neuronal polarity through regulation of microtubule stability.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Involvement of YAP-1, the Homolog of Yes-Associated Protein, in the Wnt-Mediated Neuronal Polarization inG3 (Bethesda, Md.) · 2018Article
- Epothilone B Speeds Corneal Nerve Regrowth and Functional Recovery through Microtubule Stabilization and Increased Nerve Beading.Scientific reports · 2018Article
- Phosphatidylserine save-me signals drive functional recovery of severed axons inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Distinct effects of tubulin isotype mutations on neurite growth inMolecular biology of the cell · 2017Article
- Review
- Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans.F1000Research · 2016Review
- Neurodegeneration and microtubule dynamics: death by a thousand cuts.Frontiers in cellular neuroscience · 2015Review
- A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegans.Lab on a chip · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules have been known for decades to be basic elements of the cytoskeleton. They form long, dynamic, rope-like structures within the cell that are essential for mitosis, maintenance of cell shape, and intracellular transport. More recently, in vitro studies have implicated microtubules as signaling molecules that, through changes in their stability, have the potential to trigger growth of axons and dendrites in developing neurons. In this study, we show that specific mutations in the Caenorhabditis elegans mec-7/β-tubulin gene cause ectopic axon formation in mechanosensory neurons in vivo. In mec-7 mutants, the ALM mechanosensory neuron forms a long ectopic neurite that extends posteriorly, a phenotype that can be mimicked in wild-type worms with a microtubule-stabilizing drug (paclitaxel), and suppressed by mutations in unc-33/CRMP2 and the kinesin-related gene, vab-8. Our results also reveal that these ectopic neurites contain RAB-3, a marker for presynaptic loci, suggesting that they have axon-like properties. Interestingly, in contrast with the excessive axonal growth observed during development, mec-7 mutants are inhibited in axonal regrowth and remodeling following axonal injury. Together our results suggest that MEC-7/β-tubulin integrity is necessary for the correct number of neurites a neuron generates in vivo and for the capacity of an axon to regenerate.
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