ArticleDiabetes care2013
Impact of prediabetic status on coronary atherosclerosis: a multivessel angioscopic study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Effects of aerobic exercises in prediabetes patients: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Pooled it
- Association between markers of glycemia and carotid intima-media thickness: the MARK study.BMC cardiovascular disorders · 2016Trial
- The association of pre-diabetes with significant coronary artery disease and ischemic mitral regurgitation in patients with non-ST-segment elevation acute coronary syndrome.American heart journal plus : cardiology research and practice · 2025Article
- Long-Term Outcomes Following Percutaneous Coronary Intervention With Rotational Atherectomy for Severely Calcified Lesions.Circulation reports · 2025Article
- Prognostic impact of prediabetes on long-term cardiovascular outcomes in patients under 35 with premature acute myocardial infarction.Diabetology & metabolic syndrome · 2025Article
- High-Risk Plaque Characteristics in Patients with Suspected Stable Coronary Artery Disease and Impaired Glucose Tolerance: A Coronary Computed Tomography Angiography Study.Journal of cardiovascular development and disease · 2025Article
- Review
- Elevated Glycated Albumin in Serum Is Associated with Adverse Cardiac Outcomes in Patients with Acute Coronary Syndrome Who Underwent Revascularization Therapy.Journal of atherosclerosis and thrombosis · 2022Article
- Influence of the Triglyceride-Glucose Index on Adverse Cardiovascular and Cerebrovascular Events in Prediabetic Patients With Acute Coronary Syndrome.Frontiers in endocrinology · 2022Article
- Article
- Prediabetes and long-term outcomes in patients with three-vessel coronary artery disease: A large single-center cohort study.Journal of diabetes investigation · 2021Observational
- Obesity and Prediabetes are Jointly Associated with Lipid Abnormalities Among Adolescents: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Impact of diabetes mellitus on the early-phase arterial healing after drug-eluting stent implantation.Cardiovascular diabetology · 2020Observational
- Cardiometabolic medicine - the US perspective on a new subspecialty.Cardiovascular endocrinology & metabolism · 2020Review
- Fasting and postprandial lipid parameters: A comparative evaluation of cardiovascular risk assessment in prediabetes and diabetes.Journal of family medicine and primary care · 2020Article
- Article
- A Case-Control Study on Risk Factors and Their Interactions with Prediabetes among the Elderly in Rural Communities of Yiyang City, Hunan Province.Journal of diabetes research · 2019Article
- Plaque Characteristics in Coronary Artery Disease Patients with Impaired Glucose Tolerance.PloS one · 2016Article
- Coronary atherosclerosis is already ongoing in pre-diabetic status: Insight from intravascular imaging modalities.World journal of diabetes · 2015Review
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if prediabetes is associated with atherosclerosis of coronary arteries, we evaluated the degree of coronary atherosclerosis in nondiabetic, prediabetic, and diabetic patients by using coronary angioscopy to identify plaque vulnerability based on yellow color intensity. RESEARCH DESIGN AND
methodsSixty-seven patients with coronary artery disease (CAD) underwent angioscopic observation of multiple main-trunk coronary arteries. According to the American Diabetes Association guidelines, patients were divided into nondiabetic (n = 16), prediabetic (n = 28), and diabetic (n = 23) groups. Plaque color grade was defined as 1 (light yellow), 2 (yellow), or 3 (intense yellow) based on angioscopic findings. The number of yellow plaques (NYPs) per vessel and maximum yellow grade (MYG) were compared among the groups.
resultsMean NYP and MYG differed significantly between the groups (P = 0.01 and P = 0.047, respectively). These indexes were higher in prediabetic than in nondiabetic patients (P = 0.02 and P = 0.04, respectively), but similar in prediabetic and diabetic patients (P = 0.44 and P = 0.21, respectively). Diabetes and prediabetes were independent predictors of multiple yellow plaques (NYPs ≥2) in multivariate logistic regression analysis (odds ratio [OR] 10.8 [95% CI 2.09-55.6], P = 0.005; and OR 4.13 [95% CI 1.01-17.0], P = 0.049, respectively).
conclusionsCoronary atherosclerosis and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable between prediabetic and diabetic patients. Slight or mild disorders in glucose metabolism, such as prediabetes, could be a risk factor for CAD, as is diabetes itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.