ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
All layers of medial entorhinal cortex receive presubicular and parasubicular inputs.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- A deep network-based model of hippocampal memory functions under normal and Alzheimer's disease conditions.Frontiers in neural circuits · 2023Article
- Retrosplenial and subicular inputs converge on superficially projecting layer V neurons of medial entorhinal cortex.Brain structure & function · 2022Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex.eLife · 2021Article
- Postnatal development of the entorhinal cortex: A stereological study in macaque monkeys.The Journal of comparative neurology · 2020Article
- Postnatal Development of Functional Projections from Parasubiculum and Presubiculum to Medial Entorhinal Cortex in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Functional Connectivity of the Parasubiculum and Its Role in Temporal Lobe Epilepsy.Neuroscience · 2019Article
- Roles of KNeuropharmacology · 2019Article
- Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys.Brain structure & function · 2017Article
- A single-cell spiking model for the origin of grid-cell patterns.PLoS computational biology · 2017Article
- Layer-Specific Organization of Local Excitatory and Inhibitory Synaptic Connectivity in the Rat Presubiculum.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex.Frontiers in systems neuroscience · 2017Article
- Architecture of the Entorhinal Cortex A Review of Entorhinal Anatomy in Rodents with Some Comparative Notes.Frontiers in systems neuroscience · 2017Review
- Differential Contribution of CaFrontiers in cellular neuroscience · 2017Article
- Noncanonical connections between the subiculum and hippocampal CA1.The Journal of comparative neurology · 2016Review
- Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.Journal of neurophysiology · 2016Article
- Article
- Functional Architecture of the Rat Parasubiculum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The medial entorhinal cortex (MEC), presubiculum (PrS), and parasubiculum (PaS) are interconnected components of the hippocampal-parahippocampal spatial-representation system. Principal cells in all layers of MEC show signs of directional tuning, overt in head direction cells present in all layers except for layer II, and covert in grid cells, which are the major spatially modulated cell type in layer II. Directional information likely originates in the head direction-vestibular system and PrS and PaS are thought to provide this information to MEC. Efferents from PaS and PrS show a selective laminar terminal distribution in MEC superficial layers II and III, respectively. We hypothesized that this anatomically determined laminar distribution does not preclude monosynaptic interaction with neurons located in deeper layers of MEC in view of the extensive apical dendrites from deeper cells reaching layers II and III. This hypothesis was tested in the rat using tilted in vitro slices in which origins and terminations of PrS and PaS fibers were maintained, as assessed using anterograde anatomical tracing. Based on voltage-sensitive dye imaging, multipatch single-cell recordings, and scanning photostimulation of caged glutamate, we report first that principal neurons in all layers of MEC receive convergent monosynaptic inputs from PrS and PaS and second, that elicited responses show layer-specific decay times and frequency-dependent facilitation. These results indicate that regardless of their selective laminar terminal distribution, PrS and PaS inputs may monosynaptically convey directional information to principal neurons in all layers of MEC through synapses on their extensive dendritic arbors.
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