ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Estradiol selectively enhances auditory function in avian forebrain neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Convergent and divergent neural circuit architectures that support acoustic communication.Frontiers in neural circuits · 2022Pooled it
- Reproductive state modulates utricular auditory sensitivity in a vocal fish.Journal of neurophysiology · 2022Article
- Auditory learning in an operant task with social reinforcement is dependent on neuroestrogen synthesis in the male songbird auditory cortex.Hormones and behavior · 2020Article
- Response properties of single neurons in higher level auditory cortex of adult songbirds.Journal of neurophysiology · 2019Article
- Article
- Seasonal variations in auditory processing in the inferior colliculus of Eptesicus fuscus.Hearing research · 2016Article
- It takes a seasoned bird to be a good listener: communication between the sexes.Current opinion in neurobiology · 2016Review
- He hears, she hears: are there sex differences in auditory processing?Developmental neurobiology · 2015Article
- Seasonal plasticity of precise spike timing in the avian auditory system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Social information embedded in vocalizations induces neurogenomic and behavioral responses.PloS one · 2014Article
- Estrogenic modulation of auditory processing: a vertebrate comparison.Frontiers in neuroendocrinology · 2013Review
- Storing maternal memories: hypothesizing an interaction of experience and estrogen on sensory cortical plasticity to learn infant cues.Frontiers in neuroendocrinology · 2013Review
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sex steroids modulate vertebrate sensory processing, but the impact of circulating hormone levels on forebrain function remains unclear. We tested the hypothesis that circulating sex steroids modulate single-unit responses in the avian telencephalic auditory nucleus, field L. We mimicked breeding or nonbreeding conditions by manipulating plasma 17β-estradiol levels in wild-caught female Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii). Extracellular responses of single neurons to tones and conspecific songs presented over a range of intensities revealed that estradiol selectively enhanced auditory function in cells that exhibited monotonic rate level functions to pure tones. In these cells, estradiol treatment increased spontaneous and maximum evoked firing rates, increased pure tone response strengths and sensitivity, and expanded the range of intensities over which conspecific song stimuli elicited significant responses. Estradiol did not significantly alter the sensitivity or dynamic ranges of cells that exhibited non-monotonic rate level functions. Notably, there was a robust correlation between plasma estradiol concentrations in individual birds and physiological response properties in monotonic, but not non-monotonic neurons. These findings demonstrate that functionally distinct classes of anatomically overlapping forebrain neurons are differentially regulated by sex steroid hormones in a dose-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.