ArticleNature methods2012
Measuring behavior of animal models: faults and remedies.
Article in Nature methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Colony demographics shape nest construction ineLife · 2026Article
- Activity-dependent neuroprotective protein (ADNP) derived peptide NAP prevents musculoskeletal abnormalities in ovariectomized mice.Frontiers in neuroscience · 2026Article
- Automated Observations of Dogs' Resting Behaviour Patterns Using Artificial Intelligence and Their Similarity to Behavioural Observations.Animals : an open access journal from MDPI · 2024Article
- Understanding the heterogeneity of anxiety using a translational neuroscience approach.Cognitive, affective & behavioral neuroscience · 2024Review
- Rodent tests of depression and anxiety: Construct validity and translational relevance.Cognitive, affective & behavioral neuroscience · 2024Review
- High mirror symmetry in mouse exploratory behavior.Frontiers in behavioral neuroscience · 2024Article
- Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice.BMC neuroscience · 2022Article
- A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders.Communications biology · 2022Article
- CircSLC7A2 protects against osteoarthritis through inhibition of the miR-4498/TIMP3 axis.Cell proliferation · 2021Article
- Aquarium: open-source laboratory software for design, execution and data management.Synthetic biology (Oxford, England) · 2021Article
- A Psychometrically Robust Screening Tool To Rapidly Identify Socially Impaired Monkeys In The General Population.Autism research : official journal of the International Society for Autism Research · 2020Article
- Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data.Nucleic acids research · 2020Article
- Article
- Embracing Complexity in Defensive Networks.Neuron · 2019Review
- Discovery reliability.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Adolescent Exploratory Strategies and Behavioral Types in the Multivariate Concentric Square FieldFrontiers in behavioral neuroscience · 2019Article
- Comparing phenotypic variation between inbred and outbred mice.Nature methods · 2018Article
- Reproducibility and replicability of rodent phenotyping in preclinical studies.Neuroscience and biobehavioral reviews · 2018Review
- Vertical exploration and dimensional modularity in mice.Royal Society open science · 2018Article
- Measuring behavior across scales.BMC biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Widely used behavioral assays need re-evaluation and validation against their intended use. We focus here on measures of chronic anxiety in mouse models and posit that widely used assays such as the open-field test are performed at the wrong time, for inadequate durations and using inappropriate mouse strains. We propose that behavioral assays be screened for usefulness on the basis of their replicability across laboratories.
Indexed as
Identifiers
23223171What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.