ArticleEukaryotic cell2013
Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- Overexpression of theJournal of fungi (Basel, Switzerland) · 2020Article
- Article
- The ESCRT System Plays an Important Role in the Germination in Candida albicans by Regulating the Expression of Hyphal-Specific Genes and the Localization of Polarity-Related Proteins.Mycopathologia · 2020Article
- SH3-class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth.Cellular microbiology · 2019Article
- Regulation ofJournal of fungi (Basel, Switzerland) · 2019Review
- The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes.Nature communications · 2018Article
- Candida albicans Hyphae: From Growth Initiation to Invasion.Journal of fungi (Basel, Switzerland) · 2018Review
- Cell Polarity in Yeast.Annual review of cell and developmental biology · 2017Review
- Generation of Fluorescent Protein Fusions in Candida Species.Journal of visualized experiments : JoVE · 2017Article
- Article
- Sec15 links bud site selection to polarised cell growth and exocytosis in Candida albicans.Scientific reports · 2016Article
- Hgc1-Cdc28-how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?Journal of microbiology (Seoul, Korea) · 2016Review
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- A role for the rap GTPase YlRsr1 in cellular morphogenesis and the involvement of YlRsr1 and the ras GTPase YlRas2 in bud site selection in the dimorphic yeast Yarrowia lipolytica.Eukaryotic cell · 2014Article
- Cdc42 GTPase dynamics control directional growth responses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Rax2 is important for directional establishment of growth sites, but not for reorientation of growth axes, during Candida albicans hyphal morphogenesis.Fungal genetics and biology : FG & B · 2013Article
- Interaction between bud-site selection and polarity-establishment machineries in budding yeast.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The extremely elongated morphology of fungal hyphae is dependent on the cell's ability to assemble and maintain polarized growth machinery over multiple cell cycles. The different morphologies of the fungus Candida albicans make it an excellent model organism in which to study the spatiotemporal requirements for constitutive polarized growth and the generation of different cell shapes. In C. albicans, deletion of the landmark protein Rsr1 causes defects in morphogenesis that are not predicted from study of the orthologous protein in the related yeast Saccharomyces cerevisiae, thus suggesting that Rsr1 has expanded functions during polarized growth in C. albicans. Here, we show that Rsr1 activity localizes to hyphal tips by the differential localization of the Rsr1 GTPase-activating protein (GAP), Bud2, and guanine nucleotide exchange factor (GEF), Bud5. In addition, we find that Rsr1 is needed to maintain the focused localization of hyphal polarity structures and proteins, including Bem1, a marker of the active GTP-bound form of the Rho GTPase, Cdc42. Further, our results indicate that tip-localized Cdc42 clusters are associated with the cell's ability to express a hyphal transcriptional program and that the ability to generate a focused Cdc42 cluster in early hyphae (germ tubes) is needed to maintain hyphal morphogenesis over time. We propose that in C. albicans, Rsr1 "fine-tunes" the distribution of Cdc42 activity and that self-organizing (Rsr1-independent) mechanisms of polarized growth are not sufficient to generate narrow cell shapes or to provide feedback to the transcriptional program during hyphal morphogenesis.
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