ArticleInternational journal of oral science2012
The photodynamic therapy on Streptococcus mutans biofilms using erythrosine and dental halogen curing unit.
Article in International journal of oral science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02555501 (Laser Therapy Associated With Photodynamic Therapy in the Treatment of Oral Mucositis Induced by Chemotherapy in Young Patients), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Laser Therapy Associated With Photodynamic Therapy in the Treatment of Oral Mucositis Induced by Chemotherapy in Young Patients: Randomized Blind Clinical Trial
Who cites it
24 citing papers in PubMed, 77 citations in OpenAlex.
- Treatment of dental plaque biofilms using photodynamic therapy: a randomised controlled study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Trial
- Effects of antibacterial photodynamic therapy on salivary mutans streptococci in 5- to 6-year-olds with severe early childhood caries.Lasers in medical science · 2019Trial
- Enamel Remineralizing Agents: State of the Art.Materials (Basel, Switzerland) · 2026Review
- Photodynamic therapy for caries management: mechanisms, applications, and perspectives.Frontiers in cellular and infection microbiology · 2026Review
- Nanozymes: a promising solution for dental antibacterial applications.RSC advances · 2024Review
- Anti-Biofilm Effect of Hybrid Nanocomposite Functionalized with Erythrosine B onMolecules (Basel, Switzerland) · 2024Article
- Antimicrobial Activity of Methylene Blue Associated with Photodynamic Therapy: In Vitro Study in Multi-Species Oral Biofilm.Pathogens (Basel, Switzerland) · 2024Article
- Simultaneous Dual-Wavelength Laser Irradiation against Implant-Adherent Biofilms ofBioengineering (Basel, Switzerland) · 2024Article
- Photoinactivation Effects of Curcumin, Nano-curcumin, and Erythrosine on Planktonic and Biofilm Cultures ofJournal of lasers in medical sciences · 2024Article
- Antimicrobial photodynamic therapy against Lactobacillus casei using curcumin, nano-curcumin, or erythrosine and a dental LED curing device.Lasers in medical science · 2023Article
- Photo- and Sono-Active Food Colorants Inactivating Bacteria.International journal of molecular sciences · 2023Article
- Article
- Smart dental materials for antimicrobial applications.Bioactive materials · 2023Article
- The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Antibacterial Photodynamic Inactivation of Fagopyrin F from Tartary Buckwheat (International journal of molecular sciences · 2021Article
- The efficacy of photodynamic inactivation with laser diode onInfectious disease reports · 2020Article
- Article
- The effect of antimicrobial photodynamic therapy against virulence genes expression in colistin-resistanceLaser therapy · 2019Article
- Effect of Photodynamic Antimicrobial Chemotherapy on Mono- and Multi-Species Cariogenic Biofilms: A Literature Review.Photomedicine and laser surgery · 2017Review
- Photodynamic Inactivation Mediated by Erythrosine and its Derivatives on Foodborne Pathogens and Spoilage Bacteria.Current microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of our study was to evaluate the effect of photodynamic therapy (PDT), using erythrosine as a photosensitizing agent and a dental halogen curing unit as a light source, on Streptococcus mutans in a biofilm phase. The S. mutans biofilms were formed in a 24-well cell culture cluster. Test groups consisted of biofilms divided into four groups: group 1: no photosensitizer or light irradiation treatment (control group); group 2: photosensitizer treatment alone; group 3: light irradiation alone; group 4: photosensitizer treatment and light irradiation. After treatments, the numbers of colony-forming unit (CFU) were counted and samples were examined by confocal laser scanning fluorescence microscopy (CLSM). Only group 4 (combined treatment) resulted in significant increases in cell death, with rates of 75% and 55% after 8 h of incubation, and 74% and 42% at 12 h, for biofilms formed in brain-heart infusion (BHI) broth supplemented with 0% or 0.1% sucrose, respectively. Therefore, PDT of S. mutans biofilms using a combination of erythrosine and a dental halogen curing unit, both widely used in dental clinics, resulted in a significant increase in cell death. The PDT effects are decreased in biofilms that form in the presence of sucrose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.