ArticleJournal of bacteriology2013
O antigen is the receptor of Vibrio cholerae serogroup O1 El Tor typing phage VP4.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
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- A PolyQ Membrane Protein of Vibrio cholerae Acts as the Receptor for Phage Infection.Journal of virology · 2021Article
- Comparative Genomics and Transcriptomics Analyses Reveal a Unique Environmental Adaptability ofMicroorganisms · 2020Article
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- Functional Specialization inmBio · 2019Article
- The outer-membrane protein TolC ofThe Journal of biological chemistry · 2018Article
- Bacteria and bacterial envelope components enhance mammalian reovirus thermostability.PLoS pathogens · 2017Article
- Characterization of Pseudomonas aeruginosa Phage C11 and Identification of Host Genes Required for Virion Maturation.Scientific reports · 2016Article
- The Resistance of Vibrio cholerae O1 El Tor Strains to the Typing Phage 919TP, a Member of K139 Phage Family.Frontiers in microbiology · 2016Article
- Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways.Infection and immunity · 2014Article
- Article
- Detection of virulence genes in environmental strains of Vibrio cholerae from estuaries in northeastern Brazil.Revista do Instituto de Medicina Tropical de Sao PauloArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophage VP4 is a lytic phage of the Vibrio cholerae serogroup O1, and it is used in phage subtyping of V. cholerae biotype El Tor. Studies of phage infection mechanisms will promote the understanding of the basis of phage subtyping as well as the genetic differences between sensitive and resistant strains. In this study, we investigated the receptor that phage VP4 uses to bind to El Tor strains of V. cholerae and found that it infects strains through adsorbing the O antigen of V. cholerae O1. In some natural isolates that are resistant to VP4 infection, mutations were identified in the wb* cluster (O-antigen gene cluster), which is responsible for the biosynthesis of O antigen. Mutations in the manB, wbeE, and wbeU genes caused failure of adsorption of VP4 to these strains, whereas the observed amino acid residue mutations within wbeW and manC have no effect on VP4 infection. Additionally, although mutations in two resistant strains were found only in manB and wbeW, complementing both genes did not restore sensitivity to VP4 infection, suggesting that other resistance mechanisms may exist. Therefore, the mechanism of VP4 infection may provide a basis for subtyping the phage. Elaborate mutations of the O antigen may imbue V. cholerae strains with resistance to phage infection.
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