ArticleJournal of bacteriology2013
Identification of a target gene and activating stimulus for the YpdA/YpdB histidine kinase/response regulator system in Escherichia coli.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
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- Lactate promotes the biofilm-to-invasive-planktonic transition inInfection and immunity · 2024Article
- A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.PLoS pathogens · 2024Article
- The S-component fold: a link between bacterial transporters and receptors.Communications biology · 2024Article
- Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.mBio · 2022Article
- Roles of Two-Component Signal Transduction Systems in Shigella Virulence.Biomolecules · 2022Review
- The Biological Significance of Pyruvate Sensing and Uptake inMicroorganisms · 2022Article
- Article
- Insights into a Pyruvate Sensing and Uptake System inJournal of bacteriology · 2021Article
- Whole genome sequencing of Enterobacter mori, an emerging pathogen of kiwifruit and the potential genetic adaptation to pathogenic lifestyle.AMB Express · 2021Article
- Function and Regulation of the Pyruvate Transporter CstA inInternational journal of molecular sciences · 2020Article
- Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but NonculturableJournal of bacteriology · 2019Article
- Article
- Peptide Transporter CstA Imports Pyruvate in Escherichia coli K-12.Journal of bacteriology · 2018Article
- Review
- Evidence of Cross-Regulation in Two Closely Related Pyruvate-Sensing Systems in Uropathogenic Escherichia coli.The Journal of membrane biology · 2018Article
- Article
- BtsT, a Novel and Specific Pyruvate/HJournal of bacteriology · 2018Article
- A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.Journal of bacteriology · 2018Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli contains 30 two-component systems (TCSs), each consisting of a histidine kinase and a response regulator. Whereas most TCSs are well characterized in this model organism, little is known about the YpdA/YpdB system. To identify YpdB-regulated genes, we compared the transcriptomes of E. coli cells overproducing either YpdB or a control protein. Expression levels of 15 genes differed by more than 1.9-fold between the two strains. A comprehensive evaluation of these genes identified yhjX as the sole target of YpdB. Electrophoretic mobility shift assays with purified YpdB confirmed its interaction with the yhjX promoter. Specifically, YpdB binds to two direct repeats of the motif GGCATTTCAT separated by an 11-bp spacer in the yhjX promoter. yhjX encodes a cytoplasmic membrane protein of unknown function that belongs to the major facilitator superfamily of transporters. Finally, we characterized the pattern of yhjX expression and identified extracellular pyruvate as a stimulus for the YpdA/YpdB system. It is suggested that YpdA/YpdB contributes to nutrient scavenging before entry into stationary phase.
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