ReviewCurrent opinion in clinical nutrition and metabolic care2013
Aging and muscle: a neuron's perspective.
Review in Current opinion in clinical nutrition and metabolic care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 4 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Mind-body training outperforms other physical activities in reducing frailty and enhancing quality of life in older adults: a network meta-analysis.Frontiers in public health · 2025Pooled it
- High-intensity interval training among middle-aged and older adults for body composition and muscle strength: A systematic review.Frontiers in public health · 2022Pooled it
- Effect of flavonoids on skeletal muscle mass, strength and physical performance in middle-aged and older adults with or without Sarcopenia: A meta-analysis of randomized controlled trials.Frontiers in nutrition · 2022Pooled it
- Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.European journal of applied physiology · 2020Trial
- Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults.The Journal of physiology · 2026Article
- Advancing standardisation of motor-cognitive dual task walking assessments: a scoping review of methodological practices in healthy older adults.BMC geriatrics · 2026Article
- Predicting cognitive frailty in older adults: an explainable machine learning model integrating radiomics and clinical features.BMC medical informatics and decision making · 2026Article
- Influences of Pre-fracture Mobility and Early Mobility on Healthcare Outcome Measures in Older Patients Undergoing Hip Fracture Surgery.Calcified tissue international · 2026Article
- Age-related changes in quadriceps stiffness and strength: a longitudinal observation in community-dwelling older adults.BMC geriatrics · 2025Observational
- The Influence of Age and Gender on Forehead Soft Tissue Thickness: A Magnetic Resonance Imaging-Based Study.Aesthetic plastic surgery · 2025Article
- The Effect of Muscle Strength and Visual Contrast Sensitivity on Fall Risk Sway Velocity Index.Journal of frailty, sarcopenia and falls · 2025Article
- Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current.GeroScience · 2025Article
- Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia.ACS pharmacology & translational science · 2025Article
- Application value of two-dimensional ultrasound and shear-wave elastography parameters in evaluating sarcopenia with essential hypertension.Quantitative imaging in medicine and surgery · 2025Article
- Osteoporosis in older patients with idiopathic normal pressure hydrocephalus.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Sarcopenia in older patients with idiopathic normal pressure hydrocephalus: an observational study from a single geriatric clinic in Turkey.Acta neurologica Belgica · 2024Observational
- Association between physical fitness tests and neuromuscular properties.European journal of applied physiology · 2024Article
- Measurement of Knee Extensor Torque During Repetitive Peripheral Magnetic Stimulation: Comparison of the Forces Induced by Different Stimulators.Annals of rehabilitation medicine · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewAge-related muscle weakness causes a staggering economic, public, and personal burden. Most research has focused on internal muscular mechanisms as the root cause to strength loss. Here, we briefly discuss age-related impairments in the brain and peripheral nerve structures that may theoretically lead to muscle weakness in old age. RECENT
findingsNeuronal atrophy in the brain is accompanied by electrical noise tied to declines in dopaminergic neurotransmission that degrades communication between neurons. Additionally, sensorimotor feedback loops that help regulate corticospinal excitability are impaired. In the periphery, there is evidence for motor unit loss, axonal atrophy, demyelination caused by oxidative damage to proteins and lipids, and modified transmission of the electrical signal through the neuromuscular junction. SUMMARY: Recent evidence clearly indicates that muscle weakness associated with aging is not entirely explained by classically postulated atrophy of muscle. In this issue, which focuses on 'Ageing: Biology and Nutrition' we will highlight new findings on how nervous system changes contribute to the aging muscle phenotype. These findings indicate that the ability to communicate neural activity to skeletal muscle is impaired with advancing age, which raises the question of whether many of these age-related neurological changes are mechanistically linked to impaired performance of human skeletal muscle. Collectively, this work suggests that future research should explore the direct link of these 'upstream' neurological adaptions and onset of muscle weakness in elders. In the long term, this new focus might lead to novel strategies to attenuate the age-related loss of muscle strength.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.