ArticleDevelopment (Cambridge, England)2013
Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Modulating the levels and activity of the retinal determination network is sufficient to induce the specification of distinct tissue fates in Drosophila.Development (Cambridge, England) · 2025Article
- Control of fate specification within the dorsal head of Drosophila melanogaster.Development (Cambridge, England) · 2024Article
- Canalizing cell fate by transcriptional repression.Molecular systems biology · 2024Review
- Two distinct functions ofmicroPublication biology · 2024Article
- Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex.Development (Cambridge, England) · 2023Article
- Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex.bioRxiv : the preprint server for biology · 2023Article
- Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.Developmental cell · 2023Article
- Development of the ocellar visual system in Drosophila melanogaster.The FEBS journal · 2022Article
- Article
- The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.Development (Cambridge, England) · 2022Article
- Article
- Inverse resource allocation between vision and olfaction across the genus Drosophila.Nature communications · 2019Article
- Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium.Development (Cambridge, England) · 2018Article
- Polycomb group (PcG) proteins and Pax6 cooperate to inhibitDevelopment (Cambridge, England) · 2018Article
- Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks.PLoS genetics · 2018Article
- The fly eye: Through the looking glass.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in theDevelopment (Cambridge, England) · 2017Article
- Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements.PLoS genetics · 2016Article
Corrections and comments
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2 authors.
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Abstract
The eye-antennal disc of Drosophila gives rise to numerous adult tissues, including the compound eyes, ocelli, antennae, maxillary palps and surrounding head capsule. The fate of each tissue is governed by the activity of unique gene regulatory networks (GRNs). The fate of the eye, for example, is controlled by a set of fourteen interlocking genes called the retinal determination (RD) network. Mutations within network members lead to replacement of the eyes with head capsule. Several studies have suggested that in these instances all retinal progenitor and precursor cells are eliminated via apoptosis and as a result the surrounding head capsule proliferates to compensate for retinal tissue loss. This model implies that the sole responsibility of the RD network is to promote the fate of the eye. We have re-analyzed eyes absent mutant discs and propose an alternative model. Our data suggests that in addition to promoting an eye fate the RD network simultaneously functions to actively repress GRNs that are responsible for directing antennal and head capsule fates. Compromising the RD network leads to the inappropriate expression of several head capsule selector genes such as cut, Lim1 and wingless. Instead of undergoing apoptosis, a population of mutant retinal progenitors and precursor cells adopt a head capsule fate. This transformation is accompanied by an adjustment of cell proliferation rates such that just enough head capsule is generated to produce an intact adult head. We propose that GRNs simultaneously promote primary fates, inhibit alternative fates and establish cell proliferation states.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.