ArticleFly
Drosophila protein interaction map (DPiM): a paradigm for metazoan protein complex interactions.
Article in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Beadex modulates haematopoiesis and innate immune defence against microbial infection in Drosophila melanogaster.Journal of cell science · 2026Article
- Protein Stability, Turnover Kinetics, and Abundance Constrain the Scaling of Protein Interaction Networks.bioRxiv : the preprint server for biology · 2026Article
- Next-generation large-scale binary protein interaction network for Drosophila melanogaster.Nature communications · 2023Article
- Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones.Development (Cambridge, England) · 2021Article
- Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis.PLoS genetics · 2021Article
- Cohesin occupancy and composition at enhancers and promoters are linked to DNA replication origin proximity inGenome research · 2019Article
- Composition of the Survival Motor Neuron (SMN) Complex inG3 (Bethesda, Md.) · 2019Article
- The Role of Systems Biologic Approach in Cell Signaling and Drug Development Responses-A Mini Review.Medical sciences (Basel, Switzerland) · 2018Review
- Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development.Pharmaceuticals (Basel, Switzerland) · 2016Review
- The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors.Nature immunology · 2016Article
- Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling.The EMBO journal · 2014Article
- The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response.The Journal of biological chemistry · 2014Article
- The Gemin associates of survival motor neuron are required for motor function in Drosophila.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times. Such diversity of protein expression and function accounts for the level of biological intricacy seen in nature. Defining protein-protein interactions in protein complexes, and establishing the when, what and where of potential interactions, is therefore crucial to understanding the cellular function of any protein-especially those that have not been well studied by traditional molecular genetic approaches. We generated a large-scale resource of affinity-tagged expression-ready clones and used co-affinity purification combined with tandem mass-spectrometry to identify protein partners of nearly 5,000 Drosophila melanogaster proteins. The resulting protein complex "map" provided a blueprint of metazoan protein complex organization. Here we describe how the map has provided valuable insights into protein function in addition to generating hundreds of testable hypotheses. We also discuss recent technological advancements that will be critical in addressing the next generation of questions arising from the map.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.