ArticleJournal of neurophysiology2013
Relationship between transcranial magnetic stimulation measures of intracortical inhibition and spectroscopy measures of GABA and glutamate+glutamine.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Clinical, neurophysiological and neurochemical effects of non-invasive electrical brain stimulation in fibromyalgia syndrome-a systematic review and meta-analysis.Frontiers in pain research (Lausanne, Switzerland) · 2025Pooled it
- Motor cortical inhibitory deficits in patients with obsessive-compulsive disorder-A systematic review and meta-analysis of transcranial magnetic stimulation literature.Frontiers in psychiatry · 2022Pooled it
- Cortical inhibition in neurofibromatosis type 1 is modulated by lovastatin, as demonstrated by a randomized, triple-blind, placebo-controlled clinical trial.Scientific reports · 2022Trial
- Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Changes in corticospinal excitability during an acute bout of resistance exercise in the elbow flexors.European journal of applied physiology · 2014Trial
- Baclofen, a GABAb receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Investigating Neurometabolite Changes in Response to Median Nerve Stimulation.Brain and behavior · 2025Article
- GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.Frontiers in aging neuroscience · 2025Article
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents.Experimental brain research · 2024Article
- GABA-edited MEGA-PRESS at 3 T: Does a measured macromolecule background improve linear combination modeling?Magnetic resonance in medicine · 2024Article
- Age and visual cortex inhibition: a TMS-MRS study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- GABA, Aging and Exercise: Functional and Intervention Considerations.Neuroscience insights · 2024Review
- Motor Cortex Inhibition and Facilitation Correlates with Fibromyalgia Compensatory Mechanisms and Pain: A Cross-Sectional Study.Biomedicines · 2023Article
- Relative Neuroadaptive Effect of Resistance Training along the Descending Neuroaxis in Older Adults.Brain sciences · 2023Review
- Monte Carlo study of metabolite correlations originating from spectral overlap.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Interhemispheric Facilitatory Effect of High-Frequency rTMS: Perspective from Intracortical Facilitation and Inhibition.Brain sciences · 2022Article
- Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults.NeuroImage · 2022Article
- The Impact of Theta-Burst Stimulation on Cortical GABA and Glutamate in Treatment-Resistant Depression: A Surface-Based MRSI Analysis Approach.Frontiers in molecular neuroscience · 2022Article
- Transcranial Magnetic Stimulation and Neocortical Neurons: The Micro-Macro Connection.Frontiers in neuroscience · 2022Review
- Motor Cortex Excitation/Inhibition Imbalance in Young Adults With Autism Spectrum Disorder: A MRS-TMS Approach.Frontiers in psychiatry · 2022Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Transcranial magnetic stimulation (TMS) can provide an index of intracortical excitability/inhibition balance. However, the neurochemical substrate of these measures remains unclear. Pharmacological studies suggest the involvement of GABAA and GABAB receptors in TMS protocols aimed at measuring intracortical inhibition, but this link remains inferential. Proton magnetic resonance spectroscopy ((1)H-MRS) permits measurement of GABA and glutamate + glutamine (Glx) concentrations in the human brain and might help in the direct empirical assessment of the relationship between TMS inhibitory measures and neurotransmitter concentrations. In the present study, MRS-derived relative concentrations of GABA and Glx measured in the left M1 of healthy participants were correlated with TMS measures of intracortical inhibition. Glx levels were found to correlate positively with TMS-induced silent period duration, whereas no correlation was found between GABA concentration and TMS measures. The present data demonstrate that specific TMS measures of intracortical inhibition are linked to shifts in cortical Glx, rather than GABA neurotransmitter levels. Glutamate might specifically interact with GABAB receptors, where higher MRS-derived Glx concentrations seem to be linked to higher levels of receptor activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.