ArticleJournal of neurophysiology2013
A model of cholinergic modulation in olfactory bulb and piriform cortex.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Reinforced Odor Representations in the Anterior Olfactory Nucleus Can Serve as Memory Traces for Conspecifics.eNeuro · 2025Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022Review
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- The maturational characteristics of the GABA input in the anterior piriform cortex may also contribute to the rapid learning of the maternal odor during the sensitive period.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Experience enhances certainty about olfactory stimuli under bulbar cholinergic control.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Input dependent modulation of olfactory bulb activity by HDB GABAergic projections.Scientific reports · 2020Article
- Rapid online learning and robust recall in a neuromorphic olfactory circuit.Nature machine intelligence · 2020Article
- The Basal Forebrain Modulates Neuronal Response in an Active Olfactory Discrimination Task.Frontiers in cellular neuroscience · 2020Article
- Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.Frontiers in behavioral neuroscience · 2019Article
- Sodium and potassium conductances in principal neurons of the mouse piriform cortex: a quantitative description.The Journal of physiology · 2018Article
- Pharmacological manipulation of the olfactory bulb modulates beta oscillations: testing model predictions.Journal of neurophysiology · 2018Article
- Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Granule cell excitability regulates gamma and beta oscillations in a model of the olfactory bulb dendrodendritic microcircuit.Journal of neurophysiology · 2016Article
- Internal Cholinergic Regulation of Learning and Recall in a Model of Olfactory Processing.Frontiers in cellular neuroscience · 2016Article
- Basal forebrain dynamics during nonassociative and associative olfactory learning.Journal of neurophysiology · 2016Article
- Functional differentiation of cholinergic and noradrenergic modulation in a biophysical model of olfactory bulb granule cells.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In this work we investigate in a computational model how cholinergic inputs to the olfactory bulb (OB) and piriform cortex (PC) modulate odor representations. We use experimental data derived from different physiological studies of ACh modulation of the bulbar and cortical circuitry and the interaction between these two areas. The results presented here indicate that cholinergic modulation in the OB significantly increases contrast and synchronization in mitral cell output. Each of these effects is derived from distinct neuronal interactions, with different groups of interneurons playing different roles. Both bulbar modulation effects contribute to more stable learned representations in PC, with pyramidal networks trained with cholinergic-modulated inputs from the bulb exhibiting more robust learning than those trained with unmodulated bulbar inputs. This increased robustness is evidenced as better recovery of memories from corrupted patterns and lower-concentration inputs as well as increased memory capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.