ArticleInternational journal of epidemiology2012
Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER).
Article in International journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 146 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER Study Using Linked Electronic Health Records
Leukocyte Counts and Initial Presentation of Cardiovascular Diseases: a CALIBER Study
Ethnicity and Incidence of Twelve Cardiovascular Diseases: A CALIBER Study
Capture and Concordance of Heart Failure Recorded in Primary Care, Hospital Admissions and National Mortality Registry: A Cohort Study In 2.1 Million People
Serum Uric Acid Levels and Initial Presentation of Cardiovascular Diseases: a CALIBER Study
Who cites it
146 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- What makes administrative data "research-ready"? A systematic review and thematic analysis of published literature.International journal of population data science · 2022Pooled it
- Differences in relative and absolute effectiveness of oral P2YHeart (British Cardiac Society) · 2018Pooled it
- Factors influencing the development of primary care data collection projects from electronic health records: a systematic review of the literature.BMC medical informatics and decision making · 2017Pooled it
- Are cardiovascular risk factors also associated with the incidence of atrial fibrillation? A systematic review and field synopsis of 23 factors in 32 population-based cohorts of 20 million participants.Thrombosis and haemostasis · 2017Pooled it
- Is real world evidence influencing practice? A systematic review of CPRD research in NICE guidances.BMC health services research · 2016Pooled it
- South Asians and coronary disease: is there discordance between effects on incidence and prognosis?Heart (British Cardiac Society) · 2013Pooled it
- Emulating a target trial in case-control designs: an application to statins and colorectal cancer.International journal of epidemiology · 2020Trial
- Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.BMJ (Clinical research ed.) · 2017Trial
- Comparison of hospital variation in acute myocardial infarction care and outcome between Sweden and United Kingdom: population based cohort study using nationwide clinical registries.BMJ (Clinical research ed.) · 2015Trial
- Association between clinical presentations before myocardial infarction and coronary mortality: a prospective population-based study using linked electronic records.European heart journal · 2014Trial
- Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people.Lancet (London, England) · 2014Trial
- Single-Multiple and Recurrent Pregnancy-Related Complications and Incident Cardiovascular Disease: A Nationwide Data Linkage Study in Wales, UK.Journal of the American Heart Association · 2026Article
- Article
- Atrial fibrillation development in the heart failure population from nationwide British linked electronic health records.ESC heart failure · 2025Article
- Machine learning identification of key genes in cardioembolic stroke and atherosclerosis: their association with pan-cancer and immune cells.European journal of medical research · 2025Article
- A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank.Scientific reports · 2025Article
- Cardioprotective drugs and heart failure/cardiomyopathy incidence in chemotherapy-treated cancer survivors of breast cancer and non-Hodgkin lymphoma: a retrospective cohort study in England.European heart journal open · 2025Article
- Gender Disparity in Oral Anticoagulation Therapy in Hospitalised Patients with Atrial Fibrillation During the Ongoing Syrian Conflict: Unbalanced Treatment in Turbulent Times.Journal of clinical medicine · 2025Article
- Use of heart failure medical therapy before and after a cancer diagnosis: A longitudinal study.ESC heart failure · 2024Article
- Refining the CHA2DS2VASc risk stratification scheme: shall we drop the sex category criterion?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
10 authors.
Funding
Abstract
The goal of cardiovascular disease (CVD) research using linked bespoke studies and electronic health records (CALIBER) is to provide evidence to inform health care and public health policy for CVDs across different stages of translation, from discovery, through evaluation in trials to implementation, where linkages to electronic health records provide new scientific opportunities. The initial approach of the CALIBER programme is characterized as follows: (i) Linkages of multiple electronic heath record sources: examples include linkages between the longitudinal primary care data from the Clinical Practice Research Datalink, the national registry of acute coronary syndromes (Myocardial Ischaemia National Audit Project), hospitalization and procedure data from Hospital Episode Statistics and cause-specific mortality and social deprivation data from the Office of National Statistics. Current cohort analyses involve a million people in initially healthy populations and disease registries with ∼10(5) patients. (ii) Linkages of bespoke investigator-led cohort studies (e.g. UK Biobank) to registry data (e.g. Myocardial Ischaemia National Audit Project), providing new means of ascertaining, validating and phenotyping disease. (iii) A common data model in which routine electronic health record data are made research ready, and sharable, by defining and curating with meta-data >300 variables (categorical, continuous, event) on risk factors, CVDs and non-cardiovascular comorbidities. (iv) Transparency: all CALIBER studies have an analytic protocol registered in the public domain, and data are available (safe haven model) for use subject to approvals. For more information, e-mail s.denaxas@ucl.ac.uk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.