ReviewNeuroscience and biobehavioral reviews2013
Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley.
Review in Neuroscience and biobehavioral reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Resting state functional connectivity changes following mindfulness-based stress reduction predict improvements in disease control for patients with asthma.Brain, behavior, and immunity · 2024Trial
- Demonstrating the ability of GABAergic cells in the zona incerta to modulate motivation.bioRxiv : the preprint server for biology · 2026Article
- Long-term sugar consumption alters extracellular dopamine and acetylcholine levels in the nucleus accumbens shell.Frontiers in behavioral neuroscience · 2026Article
- Central amygdalaNeurobiology of stress · 2026Article
- Micro and macro structural brain plastic changes induced by sexual experience in male rats.PloS one · 2025Article
- A critical review of effects on ethanol intake of the dynorphin/kappa opioid receptor system in the extended amygdala: From inhibition to stimulation.Alcohol, clinical & experimental research · 2023Review
- Contactless differentiation of pleasant and unpleasant valence: Assessment of the acoustic startle eyeblink response with infrared reflectance oculography.Behavior research methods · 2021Article
- Associations between peripheral inflammation and resting state functional connectivity in adolescents.Brain, behavior, and immunity · 2021Article
- Interactive Mechanisms of Supraspinal Sites of Opioid Analgesic Action: A Festschrift to Dr. Gavril W. Pasternak.Cellular and molecular neurobiology · 2021Review
- Bi-directional encoding of context-based odors and behavioral states by the nucleus of the lateral olfactory tract.iScience · 2021Article
- Corticosterone in the ventral hippocampus differentially alters accumbal dopamine output in drug-naïve and amphetamine-withdrawn rats.Neuropharmacology · 2020Article
- Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.Handbook of behavioral neuroscience · 2020Article
- Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood.Frontiers in aging neuroscience · 2018Article
- Alterations in functional brain networks associated with loss-chasing in gambling disorder and cocaine-use disorder.Drug and alcohol dependence · 2017Article
- Citalopram Ameliorates Synaptic Plasticity Deficits in Different Cognition-Associated Brain Regions Induced by Social Isolation in Middle-Aged Rats.Molecular neurobiology · 2017Article
- Blockade of glutamatergic transmission in the primate basolateral amygdala suppresses active behavior without altering social interaction.Behavioral neuroscience · 2017Article
- Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington's Disease Mouse Model.Molecular neurobiology · 2016Article
- Emotion-induced loss aversion and striatal-amygdala coupling in low-anxious individuals.Social cognitive and affective neuroscience · 2016Article
- Nucleus Accumbens Core and Shell Differentially Encode Reward-Associated Cues after Reinforcer Devaluation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.Nature communications · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
In MacLean's triune brain, the amygdala putatively subserves motivated behavior by modulating the "reptilian" basal ganglia. Accordingly, Ann Kelley, with Domesick and Nauta, influentially showed that amygdalostriatal projections are much more extensive than were appreciated. They highlighted that amygdalar projections to the rostral ventromedial striatum converged with projections from the ventral tegmental area and cingulate cortex, forming a "limbic striatum". Caudal of the anterior commissure, the entire striatum receives afferents from deep basal nuclei of the amygdala. Orthologous topographic projections subsequently were observed in fish, amphibians, and reptiles. Subsequent functional studies linked acquired value to action via this neuroanatomical substrate. From Dr. Kelley's work evolved insights into components of the distributed, interconnected network that subserves motivated behavior, including the nucleus accumbens shell and core and the striatal-like extended amygdala macrostructure. These heuristic frameworks provide a neuroanatomical basis for adaptively translating motivation into behavior. The ancient amygdala-to-striatum pathways remain a current functional thread not only for stimulus-response valuation, but also for the psychopathological plasticity that underlies addiction-related memory, craving and relapse.
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