ArticleJournal of lipid research2013
Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate.
Article in Journal of lipid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 47 citations in OpenAlex.
- PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation.Nature communications · 2022Article
- MicroRNAs and Circular RNAs in Lipoprotein Metabolism.Current atherosclerosis reports · 2021Review
- Lyophilized Maqui (Antioxidants (Basel, Switzerland) · 2021Article
- FSP27 and Links to Obesity and Diabetes Mellitus.Current obesity reports · 2019Review
- CIDE Proteins in Human Health and Disease.Cells · 2019Review
- Fat-specific protein 27 is a novel target gene of liver X receptor α.Molecular and cellular endocrinology · 2018Article
- Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in LdlrAtherosclerosis · 2018Article
- Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.Cell metabolism · 2017Article
- A Systems Biology Approach Using Transcriptomic Data Reveals Genes and Pathways in Porcine Skeletal Muscle Affected by Dietary Lysine.International journal of molecular sciences · 2017Article
- Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance.Journal of lipid research · 2017Article
- Insulin Represses Fasting-Induced Expression of Hepatic Fat-Specific Protein 27.Biological & pharmaceutical bulletin · 2017Article
- Alcohol and fat promote steatohepatitis: a critical role for fat-specific protein 27/CIDEC.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016Review
- Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes.The Journal of biological chemistry · 2016Article
- Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis.Archives of biochemistry and biophysics · 2015Article
- CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis.Hepatology (Baltimore, Md.) · 2015Article
- Impact of nutrients on circadian rhythmicity.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis.Hepatology (Baltimore, Md.) · 2015Article
- Regulation of FSP27 protein stability by AMPK and HSC70.American journal of physiology. Endocrinology and metabolism · 2014Article
- Fasting regulates FSP27 expression in the liver.Journal of lipid research · 2013Article
- Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver.Biological & pharmaceutical bulletin · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FSP27 [cell death-inducing DFFA-like effector c (CIDEC) in humans] is a protein associated with lipid droplets that downregulates the fatty acid oxidation (FAO) rate when it is overexpressed. However, little is known about its physiological role in liver. Here, we show that fasting regulates liver expression of Fsp27 in a time-dependent manner. Thus, during the initial stages of fasting, a maximal induction of 800-fold was achieved, whereas during the later phase of fasting, Fsp27 expression decreased. The early response to fasting can be explained by a canonical PKA-CREB-CRTC2 signaling pathway because: i) CIDEC expression was induced by forskolin, ii) Fsp27 promoter activity was increased by CREB, and iii) Fsp27 expression was upregulated in the liver of Sirt1 knockout animals. Interestingly, pharmacological (etomoxir) or genetic (Hmgcs2 interference) inhibition of the FAO rate increases the in vivo expression of Fsp27 during fasting. Similarly, CIDEC expression was upregulated in HepG2 cells by either etomoxir or HMGCS2 interference. Our data indicate that there is a kinetic mechanism of autoregulation between short- and long-term fasting, by which free FAs delivered to the liver during early fasting are accumulated/exported by FSP27/CIDEC, whereas over longer periods of fasting, they are degraded in the mitochondria through the carnitine palmitoyl transferase system.
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