ArticleNeuroImage2013
Category-specific semantic memory: converging evidence from bold fMRI and Alzheimer's disease.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Distinct theta and alpha electrophysiological dynamics during audiovisual semantic processing in healthy aging and mild cognitive impairment.Aging brain · 2026Article
- What we mean when we say semantic: Toward a multidisciplinary semantic glossary.Psychonomic bulletin & review · 2025Review
- Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words.GeroScience · 2024Article
- Bayesian modelling disentangles language versus executive control disruption in stroke.Brain communications · 2024Article
- Bigram semantic distance as an index of continuous semantic flow in natural language: Theory, tools, and applications.Journal of experimental psychology. General · 2023Article
- Spatial source phase: A new feature for identifying spatial differences based on complex-valued resting-state fMRI data.Human brain mapping · 2019Article
- Category learning in Alzheimer's disease and normal cognitive aging depends on initial experience of feature variability.Neuropsychologia · 2017Article
- A unified model of human semantic knowledge and its disorders.Nature human behaviour · 2017Article
- Dissociable substrates underlie the production of abstract and concrete nouns.Brain and language · 2017Article
- The Mental Status Examination in Patients With Suspected Dementia.Continuum (Minneapolis, Minn.) · 2016Review
- Impaired cognitive flexibility in amyotrophic lateral sclerosis.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2015Article
- ALS-Plus syndrome: non-pyramidal features in a large ALS cohort.Journal of the neurological sciences · 2014Article
- Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.Neurology · 2014Article
- Action verb comprehension in amyotrophic lateral sclerosis and Parkinson's disease.Journal of neurology · 2014Article
- Frontotemporal neural systems supporting semantic processing in Alzheimer's disease.Cognitive, affective & behavioral neuroscience · 2014Article
- Neural substrates of similarity and rule-based strategies in judgment.Frontiers in human neuroscience · 2014Article
- Comparative semantic profiles in semantic dementia and Alzheimer's disease.Brain : a journal of neurology · 2013Article
- Age-related vulnerability in the neural systems supporting semantic processing.Frontiers in aging neuroscience · 2013Article
- Scene categorization in Alzheimer's disease: a saccadic choice task.Dementia and geriatric cognitive disorders extraArticle
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with Alzheimer's disease have category-specific semantic memory difficulty for natural relative to manufactured objects. We assessed the basis for this deficit by asking healthy adults and patients to judge whether pairs of words share a feature (e.g. "banana:lemon-COLOR"). In an fMRI study, healthy adults showed gray matter (GM) activation of temporal-occipital cortex (TOC) where visual-perceptual features may be represented, and prefrontal cortex (PFC) which may contribute to feature selection. Tractography revealed dorsal and ventral stream white matter (WM) projections between PFC and TOC. Patients had greater difficulty with natural than manufactured objects. This was associated with greater overlap between diseased GM areas correlated with natural kinds in patients and fMRI activation in healthy adults for natural kinds. The dorsal WM projection between PFC and TOC in patients correlated only with judgments of natural kinds. Patients thus remained dependent on the same neural network as controls during judgments of natural kinds, despite disease in these areas. For manufactured objects, patients' judgments showed limited correlations with PFC and TOC GM areas activated by controls, and did not correlate with the PFC-TOC dorsal WM tract. Regions outside of the PFC-TOC network thus may help support patients' judgments of manufactured objects. We conclude that a large-scale neural network for semantic memory implicates both feature knowledge representations in modality-specific association cortex and heteromodal regions important for accessing this knowledge, and that patients' relative deficit for natural kinds is due in part to their dependence on this network despite disease in these areas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.