ArticlePhysiology & behavior2013
Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF.
Article in Physiology & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- Caffeine and Exercise in Obesity-Associated Brain Aging and Neurodegeneration: Mechanistic Insights into AMPK/SIRT1/PGC-1α, BDNF/TrkB, and NLRP3 Inflammasome Signaling.Molecular neurobiology · 2026Review
- Peripheral extracellular vesicles in neurodegeneration: pathogenic influencers and therapeutic vehicles.Journal of nanobiotechnology · 2024Review
- Review of Plant Extracts and Active Components: Mechanisms of Action for the Treatment of Obesity-Induced Cognitive Impairment.Brain sciences · 2023Review
- Modulation of High-Fat Diet-Induced Brain Oxidative Stress by Ferulate-Rich Germinated Brown Rice Ethyl Acetate Extract.Molecules (Basel, Switzerland) · 2022Article
- Neuroprotective Effect of Caffeine in Alzheimer's Disease.Molecules (Basel, Switzerland) · 2022Review
- Breakdown of the blood-brain barrier: A mediator of increased Alzheimer's risk in patients with metabolic disorders?Journal of neuroendocrinology · 2022Review
- Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes.Computational and mathematical methods in medicine · 2020Article
- Caffeine enhances activity thermogenesis and energy expenditure in rats.Clinical and experimental pharmacology & physiology · 2019Article
- Long-term Treatment with Low-Dose Caffeine Worsens BPSD-Like Profile in 3xTg-AD Mice Model of Alzheimer's Disease and Affects Mice with Normal Aging.Frontiers in pharmacology · 2018Article
- Effects of Hypericum scabrum extract on learning and memory and oxidant/antioxidant status in rats fed a long-term high-fat diet.Metabolic brain disease · 2017Article
- Botanicals as Modulators of Neuroplasticity: Focus on BDNF.Neural plasticity · 2017Review
- Role of Adiposity-Driven Inflammation in Depressive Morbidity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview.AIMS public health · 2016Review
- Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and Therapy.Molecular neurobiology · 2015Article
- Urine and serum metabolite profiling of rats fed a high-fat diet and the anti-obesity effects of caffeine consumption.Molecules (Basel, Switzerland) · 2015Article
- Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity.Frontiers in neuroscience · 2015Review
- Matching Diabetes and Alcoholism: Oxidative Stress, Inflammation, and Neurogenesis Are Commonly Involved.Mediators of inflammation · 2015Review
- Neuropsychiatric comorbidity in obesity: role of inflammatory processes.Frontiers in endocrinology · 2014Review
- Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obesity, high-fat diets, and subsequent type 2 diabetes (T2DM) are associated with cognitive impairment. Moreover, T2DM increases the risk of Alzheimer's disease (AD) and leads to abnormal elevation of brain beta-amyloid levels, one of the hallmarks of AD. The psychoactive alkaloid caffeine has been shown to have therapeutic potential in AD but the central impact of caffeine has not been well-studied in the context of a high-fat diet. Here we investigated the impact of caffeine administration on metabolism and cognitive performance, both in control rats and in rats placed on a high-fat diet. The effects of caffeine were significant: caffeine both (i) prevented the weight-gain associated with the high-fat diet and (ii) prevented cognitive impairment. Caffeine did not alter hippocampal metabolism or insulin signaling, likely because the high-fat-fed animals did not develop full-blown diabetes; however, caffeine did prevent or reverse a decrease in hippocampal brain-derived neurotrophic factor (BDNF) seen in high-fat-fed animals. These data confirm that caffeine may serve as a neuroprotective agent against cognitive impairment caused by obesity and/or a high-fat diet. Increased hippocampal BDNF following caffeine administration could explain, at least in part, the effects of caffeine on cognition and metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.