ReviewInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2013
Epigenetic control of neurotransmitter expression in olfactory bulb interneurons.
Review in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Olfactory bulb anomalies in KBG syndrome mouse model and patients.BMC medicine · 2024Article
- STAMarker: determining spatial domain-specific variable genes with saliency maps in deep learning.Nucleic acids research · 2023Article
- Inhalation of polycarbonate emissions generated during 3D printing processes affects neuroendocrine function in male rats.Journal of toxicology and environmental health. Part A · 2023Article
- Characterization by Gene Expression Analysis of Two Groups of Dopaminergic Cells Isolated from the Mouse Olfactory Bulb.Biology · 2023Article
- Brief sensory deprivation triggers plasticity of dopamine-synthesising enzyme expression in genetically labelled olfactory bulb dopaminergic neurons.The European journal of neuroscience · 2022Article
- Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb.Frontiers in neural circuits · 2021Review
- Early Postnatal Manganese Exposure Reduces Rat Cortical and Striatal Biogenic Amine Activity in Adulthood.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron.eLife · 2018Article
- Odorant Sensory Input Modulates DNA Secondary Structure Formation and Heterogeneous Ribonucleoprotein Recruitment on the Tyrosine Hydroxylase and Glutamic Acid Decarboxylase 1 Promoters in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cortical interneuron specification: the juncture of genes, time and geometry.Current opinion in neurobiology · 2017Review
- Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective.Frontiers in neuroanatomy · 2017Review
- Epigenetic Suppression of GADs Expression is Involved in Temporal Lobe Epilepsy and Pilocarpine-Induced Mice Epilepsy.Neurochemical research · 2016Article
- Molecular pathways associated with the nutritional programming of plant-based diet acceptance in rainbow trout following an early feeding exposure.BMC genomics · 2016Article
- Adult Born Olfactory Bulb Dopaminergic Interneurons: Molecular Determinants and Experience-Dependent Plasticity.Frontiers in neuroscience · 2016Review
- A distinct subtype of dopaminergic interneuron displays inverted structural plasticity at the axon initial segment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Epigenetic regulation of the neural transcriptome and alcohol interference during development.Frontiers in genetics · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Defining the molecular mechanisms that underlie development and maintenance of neuronal phenotypic diversity in the CNS is a fundamental challenge in developmental neurobiology. The vast majority of olfactory bulb (OB) interneurons are GABAergic and this neurotransmitter phenotype is specified in migrating neuroblasts by transcription of either or both glutamic acid decarboxylase 1 (Gad1) and Gad2. A subset of OB interneurons also co-express dopamine, but transcriptional repression of tyrosine hydroxylase (Th) suppresses the dopaminergic phenotype until these neurons terminally differentiate. In mature OB interneurons, GABA and dopamine levels are modulated by odorant-induced synaptic activity-dependent regulation of Gad1 and Th transcription. The molecular mechanisms that specify and maintain the GABAergic and dopaminergic phenotypes in the OB are not clearly delineated. In this report, we review previous studies and present novel findings that provide insight into the contribution of epigenetic regulatory mechanisms for controlling expression of these neurotransmitter phenotypes in the OB. We show that HDAC enzymes suppress the dopaminergic phenotype in migrating neuroblasts by repressing Th transcription. In the mature interneurons, both Th and Gad1 transcription levels are modulated by synaptic activity-dependent recruitment of acetylated Histone H3 on both the Th and Gad1 proximal promoters. We also show that HDAC2 has the opposite transcriptional response to odorant-induced synaptic activity when compared to Th and Gad1. These findings suggest that HDAC2 mediates, in part, the activity-dependent chromatin remodeling of the Th and Gad1 proximal promoters in mature OB interneurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.