Evidence map›Paper›PMID 23220129›Full record

ReviewJournal of molecular and cellular cardiology2013

Ca²⁺ waves in the heart.

Leighton T Izu, Yuanfang Xie, Daisuke Sato, Tamás Bányász, Ye Chen-Izu

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leighton T IzuDepartment of Pharmacology, University of California, Davis, USA. ltizu@ucdavis.edu
Yuanfang Xie
Daisuke Sato
Tamás Bányász
Ye Chen-Izu

Funding

The Functional Connectome of the Mechanically Loaded CardiomyocyteR01HL149431 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE, IZU, LEIGHTON T. · 2020 to 2023
$2.7M
Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System inR01HL090880 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IZU, LEIGHTON T. · 2009 to 2012
$1.5M
Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced ArrhythmiasR00HL111334 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SATO, DAISUKE · 2015 to 2017
$738k
Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced ArrhythmiasK99HL111334 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SATO, DAISUKE · 2012 to 2013
$194k
CaMKII Inhibition as a New Therapeutic Strategy for Treating Hypertension-inducedR03AG031944 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2009 to 2010
$125k
NHLBI NIH HHS K99 HL111334NHLBI NIH HHS R00 HL111334NHLBI NIH HHS R01 HL090880NHLBI NIH HHS R01 HL149431NIA NIH HHS R03 AG031944
6 · The paper itself

Abstract

Ca(2+) waves were probably first observed in the early 1940s. Since then Ca(2+) waves have captured the attention of an eclectic mixture of mathematicians, neuroscientists, muscle physiologists, developmental biologists, and clinical cardiologists. This review discusses the current state of mathematical models of Ca(2+) waves, the normal physiological functions Ca(2+) waves might serve in cardiac cells, as well as how the spatial arrangement of Ca(2+) release channels shape Ca(2+) waves, and we introduce the idea of Ca(2+) phase waves that might provide a useful framework for understanding triggered arrhythmias.

Indexed as

Models, TheoreticalArrhythmias, CardiacCalciumCalcium SignalingHumansMyocardiumRyanodine Receptor Calcium Release ChannelCalciumRyanodine Receptor Calcium Release Channel

Identifiers

PMID23220129
PMCPMC3660086

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.