ArticleAmerican journal of ophthalmology2013
Clinical phenotypes and prognostic full-field electroretinographic findings in Stargardt disease.
Article in American journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trial.EClinicalMedicine · 2025Article
- Pooled Analysis of Three MicroShunt Studies in Primary Open-Angle Glaucoma Evaluating Different Concentrations of Applied Mitomycin C.Ophthalmology and therapy · 2025Article
- Abca4, mutated in Stargardt disease, is required for structural integrity of cone outer segments.Disease models & mechanisms · 2025Article
- Prognostication in Stargardt Disease Using Fundus Autofluorescence: Improving Patient Care.Ophthalmology · 2023Article
- The Direct Healthcare Cost of Stargardt Disease: A Claims-Based Analysis.Ophthalmic epidemiology · 2021Article
- The Clinical Contribution of Full-Field Electroretinography and 8-Year Experiences of Application in a Tertiary Medical Center.Journal of personalized medicine · 2021Article
- Prediction of Function in ABCA4-Related Retinopathy Using Ensemble Machine Learning.Journal of clinical medicine · 2020Article
- Comparison of Green Versus Blue Fundus Autofluorescence inTranslational vision science & technology · 2018Article
- Peripheral Visual Fields in ABCA4 Stargardt Disease and Correlation With Disease Extent on Ultra-widefield Fundus Autofluorescence.American journal of ophthalmology · 2017Article
- Juvenile Macular Degenerations.Seminars in pediatric neurology · 2017Review
- Complex inheritance of ABCA4 disease: four mutations in a family with multiple macular phenotypes.Human genetics · 2016Article
- Predicting Progression of ABCA4-Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front.Investigative ophthalmology & visual science · 2015Article
- Macular function and morphologic features in juvenile stargardt disease: longitudinal study.Ophthalmology · 2014Article
- Psychophysical measurement of rod and cone thresholds in stargardt disease with full-field stimuli.Retina (Philadelphia, Pa.) · 2014Article
- Visual Function Measurements in Eyes With Diabetic Retinopathy: An Expert Opinion on Available Measures.Ophthalmology scienceReview
- Clinical and electroretinographic profile of 27 patients with Stargardt disease treated at a hospital in Brazil.Arquivos brasileiros de oftalmologiaObservational
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the relationships between clinical and full-field electroretinographic (ERG) findings and progressive loss of visual function in Stargardt disease.
designRetrospective cohort study.
methodsWe performed a retrospective review of data from 198 patients with Stargardt disease. Measures of visual function over time, including visual acuity, quantified Goldmann visual fields, and full-field ERG data were recorded. Data were analyzed using SAS statistical software. Subgroup analyses were performed on 148 patients with ERG phenotypic data, 46 patients with longitudinal visual field data, and 92 patients with identified ABCA4 mutations (46 with 1 mutation, and 47 with 2 or more mutations).
resultsOf 46 patients with longitudinal visual field data, 8 patients with faster central scotoma progression rates had significantly worse scotopic B-wave amplitudes at their initial assessment than 20 patients with stable scotomata (P = .014) and were more likely to have atrophy beyond the arcades (P = .047). Overall, 47.3% of patients exhibited abnormal ERG results, with rod-cone dysfunction in 14.2% of patients, cone-rod dysfunction in 17.6% of patients, and isolated cone dysfunction in 15.5% of patients. Abnormal values in certain ERG parameters were associated significantly with (maximum-stimulation A- and B-wave amplitudes) or tended toward (photopic and scotopic B-wave amplitudes) a higher mean rate of central scotoma progression compared with those patients with normal ERG values. Scotoma size and ERG parameters differed significantly between those with a single mutation versus those with multiple mutations.
conclusionsFull-field ERG examination provides clinically relevant information regarding the severity of Stargardt disease, likelihood of central scotoma expansion, and visual acuity deterioration. Patients also may exhibit an isolated cone dystrophy on ERG examination.
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