Evidence map›Paper›PMID 23219108›Full record

Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2013

Effect of a high-protein diet on kidney function in healthy adults: results from the OmniHeart trial.

Stephen P Juraschek, Lawrence J Appel, Cheryl A M Anderson, Edgar R Miller

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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  11. Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression.Clinical journal of the American Society of Nephrology : CJASN · 2015
    Trial
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  13. Common questions and misconceptions about diets: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition · 2026
    Review
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  16. Influence ofAnimals : an open access journal from MDPI · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stephen P JuraschekJohns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
Lawrence J Appel
Cheryl A M Anderson
Edgar R Miller
Johns Hopkins University · US

Funding

CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Dietary carbohydrate & glycemic index effects on oxidation & inflammationR01HL095448 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MILLER, EDGAR RAYMOND · 2009 to 2012
$625k
NHLBI NIH HHS R01 HL095448NHLBI NIH HHS R01HL095448NHLBI NIH HHS T32 HL007024NHLBI NIH HHS T32HL007024
6 · The paper itself

Abstract

backgroundConsumption of a diet high in protein can cause glomerular hyperfiltration, a potentially maladaptive response, which may accelerate the progression of kidney disease. STUDY

designAn ancillary study of the OmniHeart trial, a randomized 3-period crossover feeding trial testing the effects of partial replacement of carbohydrate with protein on kidney function. SETTING &

participantsHealthy adults (N=164) with prehypertension or stage 1 hypertension at a community-based research clinic with a metabolic kitchen.

interventionParticipants were fed each of 3 diets for 6 weeks. Feeding periods were separated by a 2- to 4-week washout period. Weight was held constant on each diet. The 3 diets emphasized carbohydrate, protein, or unsaturated fat; dietary protein was either 15% (carbohydrate and unsaturated fat diets) or 25% (protein diet) of energy intake. OUTCOMES: Fasting serum creatinine, cystatin C, and β2-microglobulin levels, estimated glomerular filtration rate (eGFR). MEASUREMENTS: Serum creatinine, cystatin C, and β2-microglobulin collected at the end of each feeding period.

resultsBaseline cystatin C-based eGFR was 92.0±16.3 (SD) mL/min/1.73 m(2). Compared with the carbohydrate and unsaturated fat diets, the protein diet increased cystatin C-based eGFR by ~4 mL/min/1.73 m(2) (P < 0.001). The effects of the protein diet on kidney function were independent of changes in blood pressure. There was no significant difference between the carbohydrate and unsaturated fat diets. LIMITATIONS: Participants did not have kidney disease at baseline.

conclusionsA healthy diet rich in protein increased eGFR. Whether long-term consumption of a high-protein diet leads to kidney disease is uncertain.

Indexed as

AdultCreatinineCystatin CDietary ProteinsFemaleGlomerular Filtration RateHumansHypertensionMaleMiddle AgedPrehypertensionCreatinineCystatin CDietary Proteins

Identifiers

PMID23219108
PMCPMC3602135
OpenAlexW2133175206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.